Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3827988..3828607 Replicon chromosome
Accession NZ_CP054063
Organism Klebsiella pneumoniae strain WSHvKP

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag HQ868_RS18630 Protein ID WP_173424244.1
Coordinates 3828389..3828607 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HQ868_RS18625 Protein ID WP_002892066.1
Coordinates 3827988..3828362 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ868_RS18615 3823140..3824333 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HQ868_RS18620 3824356..3827502 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit -
HQ868_RS18625 3827988..3828362 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HQ868_RS18630 3828389..3828607 + 219 WP_173424244.1 hemolysin expression modulator Hha Toxin
HQ868_RS18635 3828766..3829332 + 567 WP_002892030.1 maltose O-acetyltransferase -
HQ868_RS18640 3829304..3829444 - 141 WP_004147370.1 hypothetical protein -
HQ868_RS18645 3829465..3829935 + 471 WP_002892026.1 YlaC family protein -
HQ868_RS18650 3829910..3831361 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HQ868_RS18655 3831462..3832160 + 699 WP_040220001.1 GNAT family N-acetyltransferase -
HQ868_RS18660 3832157..3832297 - 141 WP_040219999.1 type B 50S ribosomal protein L36 -
HQ868_RS18665 3832297..3832560 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8662.02 Da        Isoelectric Point: 8.9008

>T158648 WP_173424244.1 NZ_CP054063:3828389-3828607 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRFRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T158648 NZ_CP069707:2759978-2760085 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT158648 WP_002892066.1 NZ_CP054063:3827988-3828362 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT158648 NZ_CP069707:c2759931-2759865 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References