Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2578435..2580023 Replicon chromosome
Accession NZ_CP054063
Organism Klebsiella pneumoniae strain WSHvKP

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HQ868_RS12655 Protein ID WP_004199851.1
Coordinates 2578435..2579757 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HQ868_RS12660 Protein ID WP_002904790.1
Coordinates 2579757..2580023 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ868_RS12640 2573491..2575992 + 2502 WP_129073863.1 fimbrial biogenesis outer membrane usher protein -
HQ868_RS12645 2575980..2576984 + 1005 WP_101971203.1 type 1 fimbrial protein -
HQ868_RS12650 2577126..2578418 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HQ868_RS12655 2578435..2579757 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HQ868_RS12660 2579757..2580023 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HQ868_RS12665 2580289..2580615 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HQ868_RS12670 2580612..2581112 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HQ868_RS12675 2581090..2582469 - 1380 WP_004184021.1 purine permease -
HQ868_RS12680 2582815..2583969 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HQ868_RS12685 2583950..2584873 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2388885..2615516 226631


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T158647 WP_004199851.1 NZ_CP054063:c2579757-2578435 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T158647 NZ_CP069707:2759443-2759550 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT158647 WP_002904790.1 NZ_CP054063:c2580023-2579757 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT158647 NZ_CP069707:c2759396-2759330 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References