Detailed information of TA system TA158630

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1969175..1969697
• Replicon: chromosome
• Accession: NZ_CP054060
• Organism: Edwardsiella ictaluri strain T1-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: F8539_RS09310
• Protein ID: WP_015871319.1
• Coordinates: 1969416..1969697 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: F8539_RS09305
• Protein ID: WP_015871318.1
• Coordinates: 1969175..1969426 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8539_RS09275	1964331..1964993	-	663	WP_015871312.1	hypothetical protein	-
F8539_RS09280	1964993..1965574	-	582	WP_049640652.1	hypothetical protein	-
F8539_RS09285	1965574..1966017	-	444	WP_015871314.1	hypothetical protein	-
F8539_RS09290	1966059..1966454	-	396	WP_049640651.1	hypothetical protein	-
F8539_RS09295	1966612..1967868	-	1257	WP_198077050.1	N4-gp56 family major capsid protein	-
F8539_RS09300	1967886..1968887	-	1002	WP_015871317.1	hypothetical protein	-
F8539_RS09305	1969175..1969426	+	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F8539_RS09310	1969416..1969697	+	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F8539_RS09315	1969769..1971883	-	2115	WP_015871320.1	hypothetical protein	-
F8539_RS09320	1971880..1972752	-	873	Protein_1792	terminase	-
F8539_RS09330	1973618..1974424	-	807	Protein_1794	terminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1936155..2004122	67967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T158630 WP_015871319.1 NZ_CP054060:1969416-1969697 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T158630 NZ_CP069706:3467213-3467431 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT158630 WP_015871318.1 NZ_CP054060:1969175-1969426 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT158630 NZ_CP069706:3466813-3467187 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3