Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1119235..1119827 Replicon chromosome
Accession NZ_CP054060
Organism Edwardsiella ictaluri strain T1-1

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag F8539_RS05205 Protein ID WP_012847872.1
Coordinates 1119235..1119438 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag F8539_RS05210 Protein ID WP_015870487.1
Coordinates 1119459..1119827 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8539_RS05165 1114455..1114916 + 462 WP_015870480.1 Lrp/AsnC family transcriptional regulator -
F8539_RS05170 1114945..1115112 - 168 WP_015870481.1 hypothetical protein -
F8539_RS05175 1115215..1115553 + 339 WP_015870482.1 P-II family nitrogen regulator -
F8539_RS05180 1115575..1116855 + 1281 WP_198077273.1 ammonium transporter AmtB -
F8539_RS05185 1116889..1117755 - 867 WP_015870484.1 acyl-CoA thioesterase II -
F8539_RS05190 1117801..1118130 - 330 WP_015870485.1 MGMT family protein -
F8539_RS05200 1119108..1119215 + 108 Protein_997 IS5/IS1182 family transposase -
F8539_RS05205 1119235..1119438 - 204 WP_012847872.1 hemolysin expression modulator Hha Toxin
F8539_RS05210 1119459..1119827 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
F8539_RS05215 1120187..1123339 - 3153 WP_015870488.1 multidrug efflux RND transporter permease subunit -
F8539_RS05220 1123383..1124567 - 1185 WP_015870489.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T158629 WP_012847872.1 NZ_CP054060:c1119438-1119235 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T158629 NZ_CP069706:2660945-2661052 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT158629 WP_015870487.1 NZ_CP054060:c1119827-1119459 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT158629 NZ_CP069706:c2660895-2660832 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References