Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1119235..1119827 | Replicon | chromosome |
Accession | NZ_CP054060 | ||
Organism | Edwardsiella ictaluri strain T1-1 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | D0ZEC2 |
Locus tag | F8539_RS05205 | Protein ID | WP_012847872.1 |
Coordinates | 1119235..1119438 (-) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | C5BCY7 |
Locus tag | F8539_RS05210 | Protein ID | WP_015870487.1 |
Coordinates | 1119459..1119827 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F8539_RS05165 | 1114455..1114916 | + | 462 | WP_015870480.1 | Lrp/AsnC family transcriptional regulator | - |
F8539_RS05170 | 1114945..1115112 | - | 168 | WP_015870481.1 | hypothetical protein | - |
F8539_RS05175 | 1115215..1115553 | + | 339 | WP_015870482.1 | P-II family nitrogen regulator | - |
F8539_RS05180 | 1115575..1116855 | + | 1281 | WP_198077273.1 | ammonium transporter AmtB | - |
F8539_RS05185 | 1116889..1117755 | - | 867 | WP_015870484.1 | acyl-CoA thioesterase II | - |
F8539_RS05190 | 1117801..1118130 | - | 330 | WP_015870485.1 | MGMT family protein | - |
F8539_RS05200 | 1119108..1119215 | + | 108 | Protein_997 | IS5/IS1182 family transposase | - |
F8539_RS05205 | 1119235..1119438 | - | 204 | WP_012847872.1 | hemolysin expression modulator Hha | Toxin |
F8539_RS05210 | 1119459..1119827 | - | 369 | WP_015870487.1 | Hha toxicity modulator TomB | Antitoxin |
F8539_RS05215 | 1120187..1123339 | - | 3153 | WP_015870488.1 | multidrug efflux RND transporter permease subunit | - |
F8539_RS05220 | 1123383..1124567 | - | 1185 | WP_015870489.1 | efflux RND transporter periplasmic adaptor subunit | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8103.37 Da Isoelectric Point: 5.0914
>T158629 WP_012847872.1 NZ_CP054060:c1119438-1119235 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR
Download Length: 204 bp
>T158629 NZ_CP069706:2660945-2661052 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14287.03 Da Isoelectric Point: 5.4786
>AT158629 WP_015870487.1 NZ_CP054060:c1119827-1119459 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV
Download Length: 369 bp
>AT158629 NZ_CP069706:c2660895-2660832 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A034SMG4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | C5BCY7 |