Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 897059..897722 Replicon chromosome
Accession NZ_CP054060
Organism Edwardsiella ictaluri strain T1-1

Toxin (Protein)


Gene name tad Uniprot ID C5B7U4
Locus tag F8539_RS04180 Protein ID WP_015870280.1
Coordinates 897378..897722 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag F8539_RS04175 Protein ID WP_015870279.1
Coordinates 897059..897376 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8539_RS04130 892390..892938 + 549 WP_015870271.1 YaeQ family protein -
F8539_RS04135 892940..893356 + 417 WP_015870272.1 aminoacyl-tRNA hydrolase -
F8539_RS04140 893453..894130 + 678 WP_015870273.1 envelope stress response activation lipoprotein NlpE -
F8539_RS04145 894152..894412 - 261 WP_015870274.1 YfhL family 4Fe-4S dicluster ferredoxin -
F8539_RS04150 895017..895295 + 279 WP_133175613.1 hypothetical protein -
F8539_RS04160 896240..896419 + 180 WP_071525714.1 hypothetical protein -
F8539_RS04165 896461..896652 + 192 WP_049640193.1 hypothetical protein -
F8539_RS04170 896649..897026 + 378 WP_015870278.1 type II toxin-antitoxin system death-on-curing family toxin -
F8539_RS04175 897059..897376 - 318 WP_015870279.1 helix-turn-helix domain-containing protein Antitoxin
F8539_RS04180 897378..897722 - 345 WP_015870280.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F8539_RS04185 897894..898163 - 270 Protein_796 head completion/stabilization protein -
F8539_RS04190 898195..898934 + 740 Protein_797 phage portal protein -
F8539_RS04195 899958..900805 - 848 Protein_798 MurR/RpiR family transcriptional regulator -
F8539_RS04200 900982..901605 + 624 WP_015870285.1 phosphatidylglycerophosphatase C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-86)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12544.34 Da        Isoelectric Point: 9.8474

>T158628 WP_015870280.1 NZ_CP054060:c897722-897378 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Download         Length: 345 bp

>T158628 NZ_CP069706:2660410-2660517 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11480.41 Da        Isoelectric Point: 10.2058

>AT158628 WP_015870279.1 NZ_CP054060:c897376-897059 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Download         Length: 318 bp

>AT158628 NZ_CP069706:c2660357-2660296 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5B7U4

Antitoxin

Source ID Structure

References