Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 4276699..4277290 Replicon chromosome
Accession NZ_CP054058
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag A8O29_RS21195 Protein ID WP_125354573.1
Coordinates 4276699..4277016 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag A8O29_RS21200 Protein ID WP_125354572.1
Coordinates 4277009..4277290 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS21180 4271992..4273779 + 1788 WP_125354576.1 sodium:proton antiporter -
A8O29_RS21185 4274112..4275473 + 1362 WP_125354575.1 lysine-sensitive aspartokinase 3 -
A8O29_RS21190 4275569..4276510 + 942 WP_125354574.1 ketopantoate/pantoate/pantothenate transporter PanS -
A8O29_RS21195 4276699..4277016 + 318 WP_125354573.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A8O29_RS21200 4277009..4277290 + 282 WP_125354572.1 putative addiction module antidote protein Antitoxin
A8O29_RS21205 4277337..4277609 + 273 WP_125354571.1 DUF3811 domain-containing protein -
A8O29_RS21210 4277651..4278007 - 357 WP_125354570.1 hypothetical protein -
A8O29_RS21215 4278142..4278321 + 180 WP_125354569.1 hypothetical protein -
A8O29_RS21220 4278370..4279251 - 882 WP_110511073.1 23S rRNA pseudouridine(2604) synthase RluF -
A8O29_RS21225 4279309..4280940 - 1632 WP_110511074.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11810.65 Da        Isoelectric Point: 9.9412

>T158626 WP_125354573.1 NZ_CP054058:4276699-4277016 [Scandinavium goeteborgense]
MKTILQTSVFQKWESRLKDHSAKALIAARILRLANGLPGDTKSIGEGIHELRIHYGPGYRIYFQQQNDVIILLLCGGDKS
RQSSDIVAAKYLASVYRTKEGLIHE

Download         Length: 318 bp

>T158626 NZ_CP069706:2310521-2311843 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
ATTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9845.32 Da        Isoelectric Point: 8.5555

>AT158626 WP_125354572.1 NZ_CP054058:4277009-4277290 [Scandinavium goeteborgense]
MNKLTHYDPAAALINDEAIAVFINDALETGNAAFIAKALGVVARAKGMSTIATETGLSREQLYRSFSDQGNPTLKTTLAV
MKALGFGLTIKNT

Download         Length: 282 bp

>AT158626 NZ_CP069706:2310255-2310521 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References