Detailed information of TA system TA158625

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4072099..4072697
• Replicon: chromosome
• Accession: NZ_CP054058
• Organism: Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: A8O29_RS20210
• Protein ID: WP_125354049.1
• Coordinates: 4072099..4072449 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: A8O29_RS20215
• Protein ID: WP_125354050.1
• Coordinates: 4072443..4072697 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8O29_RS20190	4067405..4068430	-	1026	WP_174081408.1	ABC transporter permease	-
A8O29_RS20195	4068441..4069946	-	1506	WP_125354046.1	sugar ABC transporter ATP-binding protein	-
A8O29_RS20200	4070162..4071118	-	957	WP_125354047.1	ABC transporter substrate-binding protein	-
A8O29_RS20205	4071413..4071940	+	528	WP_125354048.1	inorganic diphosphatase	-
A8O29_RS20210	4072099..4072449	-	351	WP_125354049.1	type II toxin-antitoxin system ChpB family toxin	Toxin
A8O29_RS20215	4072443..4072697	-	255	WP_125354050.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
A8O29_RS20220	4072914..4073258	-	345	WP_110510889.1	gamma-glutamylcyclotransferase	-
A8O29_RS20225	4073261..4077037	-	3777	WP_125354051.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-50)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12127.92 Da
• Isoelectric Point: 6.3152

>T158625 WP_125354049.1 NZ_CP054058:c4072449-4072099 [Scandinavium goeteborgense]
MVKRPGFERGDIVLVSFSPASGREQQGVSRPAIILSTAAFNRTGTALVAPITQGGSFAREAGFSVSLSGCGTETSGVVLV
NQVRMVDLEVRGARKIETAPADIVEEALARLIAIVE

Nucleotide

• Length: 351 bp

>T158625 NZ_CP069706:2001066-2001169 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9320.81 Da
• Isoelectric Point: 4.5510

>AT158625 WP_125354050.1 NZ_CP054058:c4072697-4072443 [Scandinavium goeteborgense]
MRIVIKKWGNSTGMVIPGVVVKELGLSAGQSMEAEVINNQLILTPVARKRYTLEQLLAECDLDAPKISEEEVWGKDNPLG
NEVW

Nucleotide

• Length: 255 bp

>AT158625 NZ_CP069706:c2001207-2000936 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT