Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3499525..3500146 Replicon chromosome
Accession NZ_CP054058
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag A8O29_RS17590 Protein ID WP_125355557.1
Coordinates 3499928..3500146 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag A8O29_RS17585 Protein ID WP_125355559.1
Coordinates 3499525..3499899 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS17575 3494656..3495849 + 1194 WP_125355563.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
A8O29_RS17580 3495872..3499018 + 3147 WP_125355561.1 multidrug efflux RND transporter permease subunit AcrB -
A8O29_RS17585 3499525..3499899 + 375 WP_125355559.1 Hha toxicity modulator TomB Antitoxin
A8O29_RS17590 3499928..3500146 + 219 WP_125355557.1 hemolysin expression modulator Hha Toxin
A8O29_RS17595 3500296..3500850 + 555 WP_125355555.1 maltose O-acetyltransferase -
A8O29_RS17600 3500948..3501418 + 471 WP_125355553.1 YlaC family protein -
A8O29_RS17605 3501387..3502847 - 1461 WP_125355551.1 PLP-dependent aminotransferase family protein -
A8O29_RS17610 3502947..3503657 + 711 WP_125355549.1 GNAT family N-acetyltransferase -
A8O29_RS17615 3503654..3503794 - 141 WP_110511693.1 type B 50S ribosomal protein L36 -
A8O29_RS17620 3503797..3504057 - 261 WP_125355547.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.93 Da        Isoelectric Point: 7.9906

>T158624 WP_125355557.1 NZ_CP054058:3499928-3500146 [Scandinavium goeteborgense]
MSDQPLTKTDYLMRLRRCQTLDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T158624 NZ_CP069706:1754350-1754604 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAATGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14452.28 Da        Isoelectric Point: 4.8941

>AT158624 WP_125355559.1 NZ_CP054058:3499525-3499899 [Scandinavium goeteborgense]
MDEYSPKRHDLAQLKFLCETLYHDCLANLEENRAGWVNDPTSALNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSNYGINADDLQKWRKSGNRLSRCFVNLSRTNPVSLSC

Download         Length: 375 bp

>AT158624 NZ_CP069706:1754102-1754353 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References