Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2569762..2570400 Replicon chromosome
Accession NZ_CP054058
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A8O29_RS13225 Protein ID WP_047043763.1
Coordinates 2569762..2569944 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A8O29_RS13230 Protein ID WP_174081342.1
Coordinates 2569969..2570400 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS13205 2564837..2566942 - 2106 WP_174081433.1 phage terminase large subunit family protein -
A8O29_RS13210 2566942..2567433 - 492 WP_174081339.1 DUF1441 family protein -
A8O29_RS13215 2567610..2568224 - 615 WP_174081340.1 hypothetical protein -
A8O29_RS13220 2568206..2569663 - 1458 WP_174081341.1 glycosyltransferase family 2 protein -
A8O29_RS13225 2569762..2569944 + 183 WP_047043763.1 type II toxin-antitoxin system HicA family toxin Toxin
A8O29_RS13230 2569969..2570400 + 432 WP_174081342.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A8O29_RS13235 2570420..2571451 - 1032 WP_125355697.1 IS630 family transposase -
A8O29_RS13240 2571589..2571807 - 219 WP_125355278.1 hypothetical protein -
A8O29_RS13245 2571806..2572246 + 441 WP_125355279.1 hypothetical protein -
A8O29_RS13250 2572507..2573352 - 846 WP_125355282.1 cell envelope biogenesis protein OmpA -
A8O29_RS13255 2573451..2574332 - 882 WP_125355280.1 cell envelope biogenesis protein OmpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2544653..2596991 52338
- flank IS/Tn - - 2570420..2571451 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6508.74 Da        Isoelectric Point: 10.8930

>T158621 WP_047043763.1 NZ_CP054058:2569762-2569944 [Scandinavium goeteborgense]
MKSTDLIKELIAAGCELKRQGKGSHQIWWSPITGKTFPVPHPKGNLPIGTIKSIKKTAGI

Download         Length: 183 bp

>T158621 NZ_CP069706:1112664-1112999 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 16030.96 Da        Isoelectric Point: 4.1283

>AT158621 WP_174081342.1 NZ_CP054058:2569969-2570400 [Scandinavium goeteborgense]
MFFSVGVETPKDENTAYGMIVPAFSAYDYGCFSAADTQDQIAPMVKEAIMMVVEDLVQEGKASPDSIKDAGYMVYAADPE
YKDFDSWVMIDVDLSEFEGKPQRINISLPDTLIKRIDNAVKGNDTYRDRSHFLAEAARHELNN

Download         Length: 432 bp

>AT158621 NZ_CP069706:1112416-1112664 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References