Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 986931..987585 Replicon chromosome
Accession NZ_CP054058
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag A8O29_RS05570 Protein ID WP_125351755.1
Coordinates 987403..987585 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag A8O29_RS05565 Protein ID WP_125351756.1
Coordinates 986931..987344 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS05535 982681..982875 + 195 WP_174081246.1 TrmB family transcriptional regulator -
A8O29_RS05540 983023..984075 + 1053 WP_125351760.1 site-specific DNA-methyltransferase -
A8O29_RS05545 984218..985081 + 864 WP_125351759.1 cell envelope biogenesis protein OmpA -
A8O29_RS05550 985274..986116 + 843 WP_125351758.1 cell envelope biogenesis protein OmpA -
A8O29_RS05555 986210..986428 + 219 WP_125351757.1 hypothetical protein -
A8O29_RS05560 986689..986826 - 138 WP_168713813.1 hypothetical protein -
A8O29_RS05565 986931..987344 - 414 WP_125351756.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A8O29_RS05570 987403..987585 - 183 WP_125351755.1 type II toxin-antitoxin system HicA family toxin Toxin
A8O29_RS05575 987691..989157 + 1467 WP_174081247.1 glycosyltransferase family 2 protein -
A8O29_RS05580 989364..989888 + 525 WP_125351753.1 KilA-N domain-containing protein -
A8O29_RS05585 989889..990488 + 600 WP_174081248.1 hypothetical protein -
A8O29_RS05590 990664..991158 + 495 WP_125351751.1 DUF1441 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 946621..1013299 66678


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6902.00 Da        Isoelectric Point: 11.1367

>T158611 WP_125351755.1 NZ_CP054058:c987585-987403 [Scandinavium goeteborgense]
MKSSELIRRLENDGWTLDRVKGSHHTFKHPDFSNLVTVPHPSKEIKPGTLRQILRKAGIK

Download         Length: 183 bp

>T158611 NZ_CP069702:84381-85706 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAATTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCAGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15111.80 Da        Isoelectric Point: 4.7741

>AT158611 WP_125351756.1 NZ_CP054058:c987344-986931 [Scandinavium goeteborgense]
MHYPAFIEIDTDGSASGWFPDVDGCIFAGDSIEETIADAQSALDAHFEALVANDMDIPAPGKMQDHIANKEAEFTHGQWV
LVHVNMDKFDGRAERINITLPHRLLNQIDNAVKGHTEYTSRSGFLAAAARHELHKVS

Download         Length: 414 bp

>AT158611 NZ_CP069702:84083-84376 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References