Detailed information of TA system TA158608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 543749..545384
• Replicon: chromosome
• Accession: NZ_CP054058
• Organism: Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: A8O29_RS03405
• Protein ID: WP_125352403.1
• Coordinates: 544059..545384 (+)
• Length: 442 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: A8O29_RS03400
• Protein ID: WP_125352405.1
• Coordinates: 543749..544054 (+)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8O29_RS03375	538855..539430	-	576	WP_125352411.1	divisome-associated lipoprotein YraP	-
A8O29_RS03380	539440..540030	-	591	WP_110510535.1	DnaA initiator-associating protein DiaA	-
A8O29_RS03385	540057..540446	-	390	WP_125352409.1	YraN family protein	-
A8O29_RS03390	540404..542608	-	2205	WP_125352407.1	penicillin-binding protein activator	-
A8O29_RS03395	542672..543538	+	867	WP_110510532.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
A8O29_RS03400	543749..544054	+	306	WP_125352405.1	helix-turn-helix domain-containing protein	Antitoxin
A8O29_RS03405	544059..545384	+	1326	WP_125352403.1	type II toxin-antitoxin system HipA family toxin	Toxin
A8O29_RS03410	545421..547310	-	1890	WP_125352401.1	enterotoxin	-
A8O29_RS03415	547364..548155	-	792	WP_125352399.1	PTS N-acetylgalactosamine transporter subunit IID	-
A8O29_RS03420	548145..548948	-	804	WP_125352398.1	PTS N-acetylgalactosamine transporter subunit IIC	-
A8O29_RS03425	549000..549476	-	477	WP_125352396.1	PTS N-acetylgalactosamine transporter subunit IIB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (8-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-68)

Sequences

Toxin

Protein

• Length: 442 a.a.
• Molecular weight: 50348.19 Da
• Isoelectric Point: 5.5049

>T158608 WP_125352403.1 NZ_CP054058:544059-545384 [Scandinavium goeteborgense]
MRRTQQRLAIWMNGIQVGYWEKFRGEDGLQYLPEWIADEQGRALSLSLPFTPGNQIWRGSVVRDYFDNLLPDSENIRRRL
AMRYHAKSLEPFDLLAELGRDCVGAIQLLNVDEQPADLYSVNFRPLSETEIASTLRNTSATLPGRQDNADDLRLSIAGAQ
EKTALLWHEAQWCLPEGNTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILEHFGIPVAKSQIAQFDDQKALVVERFD
RRWSSDRQWIVRLPQEDMCQALGVSPLRKYQADGGPGITDIMEILSHSEQAERDREVFFRAQILFWLLAATDGHAKNFSI
AVEPQSRYRLTPLYDVLSAWPVIGPGNRQISWQRCKLAMSVRGSGNYYHLNRIQRRHWINHGELTGLSCSQVESMMEEII
SRTPEVIERVSALLPDSFSAELAESIFEGMRQQCGRLAEKM

Nucleotide

• Length: 1326 bp

>T158608 NZ_CP069694:c55595-55314 [Escherichia coli H20]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11045.76 Da
• Isoelectric Point: 10.4536

>AT158608 WP_125352405.1 NZ_CP054058:543749-544054 [Scandinavium goeteborgense]
MNTVYPLKTLSHLRPLLIGFRKANGLTQKDVSERLGVTQQTYARLEASPGSASIERLFKVFTVLGVEVVLSAGPAGLVPT
SSFSMEESGIQNTLPARREKW

Nucleotide

• Length: 306 bp

>AT158608 NZ_CP069694:c55836-55585 [Escherichia coli H20]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA