Detailed information of TA system TA158606

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 114190..114798
• Replicon: chromosome
• Accession: NZ_CP054058
• Organism: Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: A8O29_RS01295
• Protein ID: WP_125354691.1
• Coordinates: 114190..114375 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: A8O29_RS01300
• Protein ID: WP_125354692.1
• Coordinates: 114391..114798 (+)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A8O29_RS01280	110699..112240	-	1542	WP_125354688.1	DHA2 family efflux MFS transporter permease subunit	-
A8O29_RS01285	112251..113429	-	1179	WP_125354689.1	efflux RND transporter periplasmic adaptor subunit	-
A8O29_RS01290	113455..113910	-	456	WP_125354690.1	MarR family transcriptional regulator	-
A8O29_RS01295	114190..114375	+	186	WP_125354691.1	type II toxin-antitoxin system HicA family toxin	Toxin
A8O29_RS01300	114391..114798	+	408	WP_125354692.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
A8O29_RS01305	114858..115349	+	492	WP_125354693.1	transposase	-
A8O29_RS01310	115456..117411	-	1956	WP_125354694.1	glycoside hydrolase family 127 protein	-
A8O29_RS01315	117422..118822	-	1401	WP_125354695.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6944.15 Da
• Isoelectric Point: 11.1481

>T158606 WP_125354691.1 NZ_CP054058:114190-114375 [Scandinavium goeteborgense]
VTSAEVIGILKKNGWIEKRTRGSHHQFCHPERPGLVTVPHPKKDIKPGTLMQIWRQAGLKH

Nucleotide

• Length: 186 bp

>T158606 NZ_CP069693:c65064-64759 [Escherichia coli H20]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15085.90 Da
• Isoelectric Point: 4.5927

>AT158606 WP_125354692.1 NZ_CP054058:114391-114798 [Scandinavium goeteborgense]
MFYPAYIHSDADGSASGFFPDVPGCYFAGDSLDAAFQDARSALTAHFETLCEMQDVIPNPDAVEHHLERQPEDFSGGQWL
LVDINMNQFDGRAERINITLPRRLLAKIDGFVLEHPRFSNRSAFLAEAARRVLLG

Nucleotide

• Length: 408 bp

>AT158606 NZ_CP069693:c65284-65066 [Escherichia coli H20]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA