Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 128778..129523 Replicon plasmid pSg66741_1
Accession NZ_CP054057
Organism Scandinavium goeteborgense strain CCUG 66741

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag A8O29_RS00680 Protein ID WP_125355908.1
Coordinates 129032..129523 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag A8O29_RS00675 Protein ID WP_125355910.1
Coordinates 128778..129044 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A8O29_RS00645 124009..124482 - 474 WP_168713907.1 conjugal transfer protein TraF -
A8O29_RS00650 124531..125260 - 730 Protein_127 Tn3 family transposase -
A8O29_RS00655 125993..126361 - 369 Protein_128 conjugal transfer protein -
A8O29_RS00660 127000..127736 - 737 Protein_129 DUF932 domain-containing protein -
A8O29_RS00665 127750..127965 - 216 WP_125355913.1 hypothetical protein -
A8O29_RS00670 128413..128571 - 159 WP_125355911.1 type I toxin-antitoxin system Hok family toxin -
A8O29_RS00675 128778..129044 + 267 WP_125355910.1 DUF1778 domain-containing protein Antitoxin
A8O29_RS00680 129032..129523 + 492 WP_125355908.1 GNAT family N-acetyltransferase Toxin
A8O29_RS00685 129949..130728 + 780 WP_125355906.1 MBL fold metallo-hydrolase -
A8O29_RS00690 130857..131831 + 975 WP_125355904.1 helix-turn-helix domain-containing protein -
A8O29_RS00695 132159..132425 + 267 WP_001567383.1 DUF1471 domain-containing protein -
A8O29_RS00700 132522..133079 + 558 WP_125355976.1 TetR/AcrR family transcriptional regulator -
A8O29_RS00705 133292..133552 + 261 WP_125355974.1 DUF1471 domain-containing protein -
A8O29_RS00710 133583..134095 + 513 WP_125355972.1 DUF417 family protein -
A8O29_RS00715 134163..134300 + 138 WP_021243014.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - vipA/tssB / vipB/tssC / clpV/tssH / acrB 1..142760 142760
- flank IS/Tn - - 124531..124908 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-147)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.37 Da        Isoelectric Point: 9.1432

>T158605 WP_125355908.1 NZ_CP054057:129032-129523 [Scandinavium goeteborgense]
VGKVTAPAPLKSTHILSEFHSGEAALDEWIRLRGLKNQSTGAARTFVVCREDSSQVIGFYSLATGSVTHAIAPGGLRRNM
PDPLPIIILARLAVDSSYHGQGLGADLLHDAVLRICRVAENIGVRAIMVHALSDAAKQFYLHHGFQPSMTQEKTLFLRLP
TAI

Download         Length: 492 bp

>T158605 NZ_CP069693:c42983-42849 [Escherichia coli H20]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10004.46 Da        Isoelectric Point: 4.5895

>AT158605 WP_125355910.1 NZ_CP054057:128778-129044 [Scandinavium goeteborgense]
MKSDVQLNIRAKEAQRALIDTAAGILHKSRTDFILDIACQAAENVILDRRMFNLDDEQYAEFIDMLDAPVTANPALDTLM
ARKPQWEK

Download         Length: 267 bp

>AT158605 NZ_CP069693:43028-43088 [Escherichia coli H20]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References