Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 2001228..2001852 Replicon chromosome
Accession NZ_CP054055
Organism Streptococcus agalactiae strain GBS47

Toxin (Protein)


Gene name parE Uniprot ID A0A076ZDW1
Locus tag HQ617_RS10150 Protein ID WP_000253103.1
Coordinates 2001228..2001575 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A076YVN5
Locus tag HQ617_RS10155 Protein ID WP_000543070.1
Coordinates 2001565..2001852 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ617_RS10130 (HQ617_10080) 1996943..1997299 - 357 WP_000105934.1 DUF1304 domain-containing protein -
HQ617_RS10135 (HQ617_10085) 1997366..1999684 - 2319 WP_000883414.1 YhgE/Pip domain-containing protein -
HQ617_RS10140 (HQ617_10090) 1999823..2000362 + 540 WP_000245858.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
HQ617_RS10145 (HQ617_10095) 2000448..2000744 - 297 WP_001052249.1 DUF4298 domain-containing protein -
HQ617_RS10150 (HQ617_10100) 2001228..2001575 - 348 WP_000253103.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ617_RS10155 (HQ617_10105) 2001565..2001852 - 288 WP_000543070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HQ617_RS10160 (HQ617_10110) 2001921..2002298 - 378 WP_000038826.1 ArpU family phage packaging/lysis transcriptional regulator -
HQ617_RS10165 (HQ617_10115) 2002273..2002425 - 153 Protein_1933 DUF1492 domain-containing protein -
HQ617_RS10170 (HQ617_10120) 2002432..2002920 - 489 WP_000891151.1 hypothetical protein -
HQ617_RS10175 (HQ617_10125) 2002993..2003550 - 558 WP_001258765.1 hypothetical protein -
HQ617_RS10180 (HQ617_10130) 2003708..2003881 - 174 WP_000694573.1 hypothetical protein -
HQ617_RS10185 (HQ617_10135) 2003878..2004135 - 258 WP_001069293.1 hypothetical protein -
HQ617_RS10190 (HQ617_10140) 2004428..2005822 - 1395 WP_000656430.1 VapE family protein -
HQ617_RS10195 (HQ617_10145) 2005834..2006691 - 858 WP_001029296.1 primase alpha helix C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1996066..2015026 18960


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(12-108)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-63)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13333.09 Da        Isoelectric Point: 5.1643

>T158603 WP_000253103.1 NZ_CP054055:c2001575-2001228 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK

Download         Length: 348 bp

>T158603 NZ_CP069692:c4490157-4489984 [Escherichia coli H20]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10605.98 Da        Isoelectric Point: 4.8430

>AT158603 WP_000543070.1 NZ_CP054055:c2001852-2001565 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI

Download         Length: 288 bp

>AT158603 NZ_CP069692:c4490481-4490185 [Escherichia coli H20]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCACTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A076ZDW1

Antitoxin

Source ID Structure
AlphaFold DB A0A076YVN5

References