Detailed information of TA system TA158602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 238928..239540
• Replicon: chromosome
• Accession: NZ_CP054055
• Organism: Streptococcus agalactiae strain GBS47

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E7D3
• Locus tag: HQ617_RS01410
• Protein ID: WP_000384859.1
• Coordinates: 238928..239263 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E7D2
• Locus tag: HQ617_RS01415
• Protein ID: WP_000259017.1
• Coordinates: 239253..239540 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQ617_RS01385 (HQ617_01375)	234126..234767	+	642	Protein_217	hypothetical protein	-
HQ617_RS01390 (HQ617_01380)	235067..235942	+	876	WP_000421240.1	hypothetical protein	-
HQ617_RS01395 (HQ617_01385)	235978..236412	+	435	WP_001220479.1	hypothetical protein	-
HQ617_RS01400 (HQ617_01390)	236729..237985	+	1257	WP_000122836.1	MobV family relaxase	-
HQ617_RS01405 (HQ617_01395)	238153..238623	+	471	WP_000130119.1	hypothetical protein	-
HQ617_RS01410 (HQ617_01400)	238928..239263	-	336	WP_000384859.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HQ617_RS01415 (HQ617_01405)	239253..239540	-	288	WP_000259017.1	hypothetical protein	Antitoxin
HQ617_RS01420 (HQ617_01410)	239943..241163	-	1221	WP_000156558.1	site-specific integrase	-
HQ617_RS01425 (HQ617_01415)	241224..241484	-	261	WP_001196072.1	helix-turn-helix domain-containing protein	-
HQ617_RS01430 (HQ617_01420)	241496..242242	-	747	WP_000966632.1	hypothetical protein	-
HQ617_RS01435 (HQ617_01425)	242428..243219	-	792	WP_001868842.1	hypothetical protein	-
HQ617_RS01440 (HQ617_01430)	243200..243733	-	534	WP_000680721.1	hypothetical protein	-
HQ617_RS01445 (HQ617_01435)	243733..244071	-	339	WP_001187920.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	232359..245446	13087

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13296.98 Da
• Isoelectric Point: 4.6565

>T158602 WP_000384859.1 NZ_CP054055:c239263-238928 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T158602 NZ_CP069692:4477567-4477944 [Escherichia coli H20]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10906.50 Da
• Isoelectric Point: 4.7271

>AT158602 WP_000259017.1 NZ_CP054055:c239540-239253 [Streptococcus agalactiae]
MVTVEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT158602 NZ_CP069692:4477146-4477520 [Escherichia coli H20]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Structures

Antitoxin

• AlphaFold DB: A0A076Z4V6