Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RelB(antitoxin) |
| Location | 2080641..2081265 | Replicon | chromosome |
| Accession | NZ_CP054054 | ||
| Organism | Streptococcus agalactiae strain SS111 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A076ZDW1 |
| Locus tag | HQ612_RS10615 | Protein ID | WP_000253103.1 |
| Coordinates | 2080641..2080988 (-) | Length | 116 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A076YVN5 |
| Locus tag | HQ612_RS10620 | Protein ID | WP_000543070.1 |
| Coordinates | 2080978..2081265 (-) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HQ612_RS10595 (HQ612_10555) | 2076356..2076712 | - | 357 | WP_000105934.1 | DUF1304 domain-containing protein | - |
| HQ612_RS10600 (HQ612_10560) | 2076779..2079097 | - | 2319 | WP_000883414.1 | YhgE/Pip domain-containing protein | - |
| HQ612_RS10605 (HQ612_10565) | 2079236..2079775 | + | 540 | WP_029140677.1 | TetR/AcrR family transcriptional regulator | - |
| HQ612_RS10610 (HQ612_10570) | 2079861..2080157 | - | 297 | WP_001052249.1 | DUF4298 domain-containing protein | - |
| HQ612_RS10615 (HQ612_10575) | 2080641..2080988 | - | 348 | WP_000253103.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| HQ612_RS10620 (HQ612_10580) | 2080978..2081265 | - | 288 | WP_000543070.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| HQ612_RS10625 (HQ612_10585) | 2081334..2081711 | - | 378 | WP_000038826.1 | ArpU family phage packaging/lysis transcriptional regulator | - |
| HQ612_RS10630 (HQ612_10590) | 2081686..2081838 | - | 153 | Protein_2028 | DUF1492 domain-containing protein | - |
| HQ612_RS10635 (HQ612_10595) | 2081845..2082333 | - | 489 | WP_000891151.1 | hypothetical protein | - |
| HQ612_RS10640 (HQ612_10600) | 2082406..2082963 | - | 558 | WP_001258765.1 | hypothetical protein | - |
| HQ612_RS10645 (HQ612_10605) | 2083121..2083294 | - | 174 | WP_000694573.1 | hypothetical protein | - |
| HQ612_RS10650 (HQ612_10610) | 2083291..2083548 | - | 258 | WP_001069293.1 | hypothetical protein | - |
| HQ612_RS10655 (HQ612_10615) | 2083841..2085235 | - | 1395 | WP_000656430.1 | VapE family protein | - |
| HQ612_RS10660 (HQ612_10620) | 2085247..2086104 | - | 858 | WP_001029296.1 | primase alpha helix C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2075479..2094439 | 18960 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13333.09 Da Isoelectric Point: 5.1643
>T158601 WP_000253103.1 NZ_CP054054:c2080988-2080641 [Streptococcus agalactiae]
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
MVSDNKTHSLIIPETVQEQLQEIKSYIETTYFSEQAGANTVNNILYGLERLEFFPEAGFNADDRVGETIYPPHNTRCIVL
GDYLAFYHILEDRKAVFVSDIIHSKQDYIKLFKKK
Download Length: 348 bp
>T158601 NZ_CP069692:c4314148-4313798 [Escherichia coli H20]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 96 a.a. Molecular weight: 10605.98 Da Isoelectric Point: 4.8430
>AT158601 WP_000543070.1 NZ_CP054054:c2081265-2080978 [Streptococcus agalactiae]
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
MHALEKNTQVNFKTNSDLLEKAKAIIAAQNLDMTASFNLFLENIVQNKALPFETDTDKERAELLAGLRAEIAKSFDDLEH
GRVYNASEVRANLGI
Download Length: 288 bp
>AT158601 NZ_CP069692:c4314393-4314142 [Escherichia coli H20]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGAGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGAGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076ZDW1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A076YVN5 |