Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 239205..239817 Replicon chromosome
Accession NZ_CP054054
Organism Streptococcus agalactiae strain SS111

Toxin (Protein)


Gene name parE Uniprot ID Q8E1X3
Locus tag HQ612_RS01415 Protein ID WP_000384858.1
Coordinates 239205..239540 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q8E1X2
Locus tag HQ612_RS01420 Protein ID WP_000255538.1
Coordinates 239530..239817 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ612_RS01390 (HQ612_01385) 234380..235009 + 630 WP_000591148.1 hypothetical protein -
HQ612_RS01395 (HQ612_01390) 235345..236220 + 876 WP_000770113.1 hypothetical protein -
HQ612_RS01400 (HQ612_01395) 236256..236690 + 435 WP_001220479.1 hypothetical protein -
HQ612_RS01405 (HQ612_01400) 237006..238262 + 1257 WP_000122832.1 MobV family relaxase -
HQ612_RS01410 (HQ612_01405) 238430..238900 + 471 WP_000130119.1 hypothetical protein -
HQ612_RS01415 (HQ612_01410) 239205..239540 - 336 WP_000384858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HQ612_RS01420 (HQ612_01415) 239530..239817 - 288 WP_000255538.1 hypothetical protein Antitoxin
HQ612_RS01425 (HQ612_01420) 240324..240614 + 291 WP_000078283.1 WXG100 family type VII secretion target -
HQ612_RS01430 (HQ612_01425) 240716..241123 + 408 WP_000749954.1 hypothetical protein -
HQ612_RS01435 (HQ612_01430) 241123..241299 + 177 WP_001868321.1 hypothetical protein -
HQ612_RS01440 (HQ612_01435) 241335..241682 + 348 WP_123948016.1 hypothetical protein -
HQ612_RS01445 (HQ612_01440) 241655..242335 + 681 WP_001865565.1 hypothetical protein -
HQ612_RS01450 (HQ612_01445) 242320..242706 + 387 WP_000259069.1 hypothetical protein -
HQ612_RS01455 (HQ612_01450) 242740..243021 + 282 WP_000052406.1 hypothetical protein -
HQ612_RS01460 (HQ612_01455) 243864..244724 + 861 WP_000477654.1 Rgg/GadR/MutR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13264.04 Da        Isoelectric Point: 5.2388

>T158600 WP_000384858.1 NZ_CP054054:c239540-239205 [Streptococcus agalactiae]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

>T158600 NZ_CP069692:c4263920-4262973 [Escherichia coli H20]
ATGGATGATTTAACCACTCTTTTTTCTGAAGTGGCTGACGCGCTTGGTATTGAGTCTGTCGCAATTGTGGAAAAAGATCA
CTATATCGTTGAGCTTTTGCAATTGCTTAAACCTCTGGTGTTCGATACTCATCAATTGGTGTTTGCCGGAGGAACCGCTC
TGGCAAAATCAGGTGTCGCACTTAATCGCATGTCGGAAGATGTGGATATCAAACTGGTGCCTAAGGATGCATTTCAGGCA
CTTTCCCGCACTCAGCGAAAAAATACCCGTAAAGAAATTGTTCAGGCAGTTTCCAGTGCAATAGCTTCATCGGGTGTGTT
CAATTTTGATGATGATTACCCAAAAGTGACGCGGGATGAATATCGTTATAATGACATACCTGTTCGTTATCCACAGCGAG
TAGTGCAGGCACCTTGTTTGCGTCCTTTTATCCGGCTGGAACTGATGGAAGCGAAGTTACTGGAGCCTTCTGAATTACGG
GATATTCATTCACTGGTAACAGGGATCACGGGAAAAGCGGCTATTGTTTCAGCGTTTCCATGCGCAACTATCATTAGCAC
ACAGGCAGAAAAGCTGGTGGCGATGTTACGTCGTACTGCGGCAGTTGTGCGAGATGTTGAGCGATTTGATGATGCATCGC
TGGTACGTCATATCTACGATACAAACTGTATTGTTGAGACGAGTCATGTTGATATGAGTCTGCTCGTTGATTTTGTTCAA
CAAACTATTGAGCAGGACATTCAGCGTTACGGCAACCAGTACCCGCAGTTTTGCGCGTCTCCAGTTGATGAGCTAAAAAT
GGGACTGGATGAGTTGGCGAACAATCCTCTCTACCAGATGCGCTATCAGCAGTTTGTTTCGCCAATGGTGTATGGAGAGC
GAAAGATCACATGGGATGAGGCTTACTCCAGGTTTAGGAGCTTAGCGCTAGCCATCCTGAATGCTTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10921.47 Da        Isoelectric Point: 4.7271

>AT158600 WP_000255538.1 NZ_CP054054:c239817-239530 [Streptococcus agalactiae]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Download         Length: 288 bp

>AT158600 NZ_CP069692:c4264308-4263913 [Escherichia coli H20]
ATGACGATAAAAGCACGCATTCAGTCACGACTGAAACGTTCTAAACGTTACGTATTCACTCGTGACGACTTTAAAGATAT
TGCAGGCTACGATCAGGTTGGTCGGGTATTGCGCGATCTTGTCAGGGAAGGGCAACTGTTGAAGGTTGGTTATGGCGTGT
ATACCAAAGCACGGCGGAACGGTATTACAGGCAAGGTAATGCCAGCGGCTCCCGGAGGCTCTTCAGCGGTGATTGTCGAA
ACGCTGGAACGCCTGAAAGTACGCTATCGTTTTGCTGGCGCAACGCAGGCATACAATAGCGGTACTTCTACGCAGATCCC
AGCTTCACCCGAGATAAAAACCCCCCGGCGTTTTAAACGCGTATTATCTGTAGGGAACAGCAGATTAAATGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1EF10

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1EFF9

References