Detailed information of TA system TA158599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1391598..1392126
• Replicon: chromosome
• Accession: NZ_CP054052
• Organism: Poseidonibacter lekithochrous strain DSM 100870

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: ALEK_RS06700
• Protein ID: WP_071625927.1
• Coordinates: 1391598..1391885 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ALEK_RS06705
• Protein ID: WP_071625926.1
• Coordinates: 1391875..1392126 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ALEK_RS06665	1386825..1387520	+	696	WP_071625933.1	ABC transporter permease	-
ALEK_RS06670	1387517..1388542	+	1026	WP_083574587.1	energy-coupling factor ABC transporter ATP-binding protein	-
ALEK_RS06675	1388545..1388811	-	267	WP_071625932.1	type II toxin-antitoxin system YafQ family toxin	-
ALEK_RS06680	1388811..1389059	-	249	WP_071625931.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
ALEK_RS06685	1389155..1390039	-	885	WP_071625930.1	hypothetical protein	-
ALEK_RS06690	1390065..1390946	-	882	WP_071625929.1	DUF4231 domain-containing protein	-
ALEK_RS06695	1390946..1391356	-	411	WP_071625928.1	TIR domain-containing protein	-
ALEK_RS06700	1391598..1391885	-	288	WP_071625927.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ALEK_RS06705	1391875..1392126	-	252	WP_071625926.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ALEK_RS06710	1392394..1393062	+	669	WP_071625925.1	hypothetical protein	-
ALEK_RS06715	1393261..1394715	+	1455	WP_197950356.1	DUF413 domain-containing protein	-
ALEK_RS06720	1394772..1396685	-	1914	WP_071625923.1	cache domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-70)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11481.49 Da
• Isoelectric Point: 10.3650

>T158599 WP_071625927.1 NZ_CP054052:c1391885-1391598 [Poseidonibacter lekithochrous]
MTYKLQFHKKALKEWDKIDSKIKEQFKKKLKERLENPKVQKDKLSGFEDVYKIKLRNAGFRLAYQVKDEEIFVIVLAVGK
RENDKIYKLLDSRFD

Nucleotide

• Length: 288 bp

>T158599 NZ_CP069692:3871340-3871618 [Escherichia coli H20]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9231.38 Da
• Isoelectric Point: 3.9953

>AT158599 WP_071625926.1 NZ_CP054052:c1392126-1391875 [Poseidonibacter lekithochrous]
MNAILSNYSASISELKKSPSSIIEEAGDEAVAILNHNKASAYLVPAQTYEKLMEIVDDYMLANKVKERIEDTDELVEVNL
DDL

Nucleotide

• Length: 252 bp

>AT158599 NZ_CP069692:3871077-3871337 [Escherichia coli H20]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA