Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4559043..4559661 Replicon chromosome
Accession NZ_CP054049
Organism Yersinia kristensenii strain 2012N-4030

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag HRD70_RS20830 Protein ID WP_002208622.1
Coordinates 4559458..4559661 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A857F2E4
Locus tag HRD70_RS20825 Protein ID WP_004392643.1
Coordinates 4559043..4559411 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD70_RS20795 4554718..4554978 + 261 WP_049557762.1 type B 50S ribosomal protein L31 -
HRD70_RS20800 4554994..4555137 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
HRD70_RS20805 4555257..4556135 - 879 WP_049557766.1 metal ABC transporter substrate-binding protein -
HRD70_RS20810 4556181..4557038 - 858 WP_032820903.1 metal ABC transporter permease -
HRD70_RS20815 4557035..4557763 - 729 WP_050095999.1 ABC transporter ATP-binding protein -
HRD70_RS20820 4558531..4558884 + 354 WP_032820904.1 hypothetical protein -
HRD70_RS20825 4559043..4559411 + 369 WP_004392643.1 Hha toxicity modulator TomB Antitoxin
HRD70_RS20830 4559458..4559661 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
HRD70_RS20840 4560614..4560964 + 351 WP_172439447.1 MGMT family protein -
HRD70_RS20845 4561008..4561532 - 525 WP_049557778.1 YbaY family lipoprotein -
HRD70_RS20850 4561790..4562650 + 861 WP_049557780.1 acyl-CoA thioesterase II -
HRD70_RS20855 4562732..4564021 - 1290 WP_049557979.1 ammonium transporter AmtB -
HRD70_RS20860 4564061..4564399 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T158597 WP_002208622.1 NZ_CP054049:4559458-4559661 [Yersinia kristensenii]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T158597 NZ_CP069692:2829819-2829926 [Escherichia coli H20]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14176.95 Da        Isoelectric Point: 4.5140

>AT158597 WP_004392643.1 NZ_CP054049:4559043-4559411 [Yersinia kristensenii]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYPDGGDLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT158597 NZ_CP069692:c2829769-2829706 [Escherichia coli H20]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTAAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A857F2E4

References