Detailed information of TA system TA158587

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 2896048..2896750
• Replicon: chromosome
• Accession: NZ_CP054049
• Organism: Yersinia kristensenii strain 2012N-4030

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HRD70_RS12860
• Protein ID: WP_050157417.1
• Coordinates: 2896382..2896750 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HRD70_RS12855
• Protein ID: WP_050157416.1
• Coordinates: 2896048..2896380 (-)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD70_RS12815	2891337..2891753	+	417	WP_050094372.1	CoA-binding protein	-
HRD70_RS12820	2891831..2892148	-	318	WP_049556065.1	heat shock protein HspQ	-
HRD70_RS12825	2892210..2893394	-	1185	WP_049556066.1	23S rRNA (cytosine(1962)-C(5))-methyltransferase RlmI	-
HRD70_RS12830	2893608..2893817	+	210	WP_049556067.1	hypothetical protein	-
HRD70_RS12835	2893922..2894200	+	279	WP_050094371.1	acylphosphatase	-
HRD70_RS12840	2894228..2894557	-	330	WP_049556069.1	sulfurtransferase TusE	-
HRD70_RS12850	2895103..2895963	-	861	WP_050157413.1	DUF4942 domain-containing protein	-
HRD70_RS12855	2896048..2896380	-	333	WP_050157416.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HRD70_RS12860	2896382..2896750	-	369	WP_050157417.1	TA system toxin CbtA family protein	Toxin
HRD70_RS12865	2896806..2897138	-	333	WP_050157420.1	hypothetical protein	-
HRD70_RS12870	2897138..2897605	-	468	WP_050157455.1	DNA repair protein RadC	-
HRD70_RS12875	2897638..2898069	-	432	WP_050157423.1	antirestriction protein	-
HRD70_RS12880	2898430..2899251	-	822	WP_050157426.1	DUF945 domain-containing protein	-
HRD70_RS12885	2899326..2899772	-	447	WP_050157429.1	hypothetical protein	-
HRD70_RS12890	2899808..2899981	-	174	WP_172672110.1	hypothetical protein	-
HRD70_RS12895	2899995..2901236	-	1242	WP_050157432.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (5-101)

Antitoxin

• Antitoxin CbeA (10-108)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13596.54 Da
• Isoelectric Point: 6.9878

>T158587 WP_050157417.1 NZ_CP054049:c2896750-2896382 [Yersinia kristensenii]
MKPRATPPGALPVSAIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEREISVGDTINALVDKYVLVRIGRNGFSALAQ
DPMLSKGDIVRARQASGLWRAHFPPTLLYPTESLNPIPHRDS

Nucleotide

• Length: 369 bp

>T158587 NZ_CP069692:958185-958592 [Escherichia coli H20]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12206.85 Da
• Isoelectric Point: 7.3204

>AT158587 WP_050157416.1 NZ_CP054049:c2896380-2896048 [Yersinia kristensenii]
MNNHITTSLTWGLKRDITPRLGARLVQDGTHLHFLSDRANIVGTFSPQATQSLDTVFPALITKLESQLLSGQLDPRRQQC
LTVRYGGFVCDADTLGSHGYVYIAVYQELS

Nucleotide

• Length: 333 bp

>AT158587 NZ_CP069692:957938-958204 [Escherichia coli H20]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA