Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2180595..2181275 Replicon chromosome
Accession NZ_CP054049
Organism Yersinia kristensenii strain 2012N-4030

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HRD70_RS09675 Protein ID WP_172986277.1
Coordinates 2180595..2180915 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HRD70_RS09680 Protein ID WP_172986278.1
Coordinates 2180952..2181275 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD70_RS09650 2175984..2176466 - 483 WP_049560719.1 lipoprotein -
HRD70_RS09655 2176557..2177297 - 741 WP_049560716.1 hypothetical protein -
HRD70_RS09660 2178153..2179085 - 933 WP_049561002.1 LysR family transcriptional regulator -
HRD70_RS09665 2179178..2179654 + 477 WP_049561007.1 GNAT family N-acetyltransferase -
HRD70_RS09670 2180064..2180243 - 180 Protein_1868 integrase arm-type DNA-binding domain-containing protein -
HRD70_RS09675 2180595..2180915 - 321 WP_172986277.1 TA system toxin CbtA family protein Toxin
HRD70_RS09680 2180952..2181275 - 324 WP_172986278.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HRD70_RS09685 2181288..2181758 - 471 WP_172986279.1 DNA repair protein RadC -
HRD70_RS09690 2181828..2182649 - 822 WP_057532575.1 DUF945 domain-containing protein -
HRD70_RS09695 2182725..2183153 - 429 WP_172986280.1 hypothetical protein -
HRD70_RS09700 2183188..2183361 - 174 WP_172986281.1 hypothetical protein -
HRD70_RS09705 2183376..2184569 - 1194 WP_172986282.1 hypothetical protein -
HRD70_RS09710 2184589..2185029 - 441 WP_172986283.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12066.82 Da        Isoelectric Point: 5.9558

>T158586 WP_172986277.1 NZ_CP054049:c2180915-2180595 [Yersinia kristensenii]
MQISTVPATVPVSPRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAILEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTANDILRARKATGLMHT

Download         Length: 321 bp

>T158586 NZ_CP069692:c797897-797520 [Escherichia coli H20]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCAGCCTGATGACCCGCGA
CAATTACCGAACAGTAAATAACATTACTCTGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11997.56 Da        Isoelectric Point: 6.4732

>AT158586 WP_172986278.1 NZ_CP054049:c2181275-2180952 [Yersinia kristensenii]
MPFTPSHEWGLQSDITPRFGARLVQEGNSLHYLADRAGLTGSFSPEQLQKLEQTFPLFIAQLENMLRSGELNPGWQHQVK
VHLAGFSCVADTRASFGYVYISIYPAQ

Download         Length: 324 bp

>AT158586 NZ_CP069692:c798318-797944 [Escherichia coli H20]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGGCCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References