Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 120289..120961 Replicon chromosome
Accession NZ_CP054049
Organism Yersinia kristensenii strain 2012N-4030

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A7TB89
Locus tag HRD70_RS00525 Protein ID WP_032819978.1
Coordinates 120289..120714 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag HRD70_RS00530 Protein ID WP_050094712.1
Coordinates 120695..120961 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD70_RS00505 116047..116565 + 519 WP_050094714.1 flavodoxin FldB -
HRD70_RS00510 116639..118060 - 1422 WP_049561882.1 cell envelope integrity protein CreD -
HRD70_RS00515 118153..119580 - 1428 WP_004390963.1 two-component system sensor histidine kinase CreC -
HRD70_RS00520 119591..120289 - 699 WP_004390964.1 two-component system response regulator CreB -
HRD70_RS00525 120289..120714 - 426 WP_032819978.1 protein YgfX Toxin
HRD70_RS00530 120695..120961 - 267 WP_050094712.1 FAD assembly factor SdhE Antitoxin
HRD70_RS00535 121373..122365 + 993 WP_049561879.1 tRNA-modifying protein YgfZ -
HRD70_RS00540 122419..123102 - 684 WP_049561877.1 hemolysin III family protein -
HRD70_RS00545 123470..124072 + 603 WP_004390971.1 HD domain-containing protein -
HRD70_RS00550 124085..124834 - 750 WP_049561874.1 SDR family oxidoreductase -
HRD70_RS00555 124869..125066 - 198 WP_050111681.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16440.32 Da        Isoelectric Point: 10.2825

>T158583 WP_032819978.1 NZ_CP054049:c120714-120289 [Yersinia kristensenii]
VAQWRCDLRVSWHTQLFSLLAHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNIKSCQGEIRLKPGNVVLWKRH
EWIVVKQPWITRHGVLLSLQQTGNRSTRKRLWLAADSMPEEEWRQLCLLLRHSFGSDEGIH

Download         Length: 426 bp

>T158583 NZ_CP069692:218499-218606 [Escherichia coli H20]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.02 Da        Isoelectric Point: 5.1405

>AT158583 WP_050094712.1 NZ_CP054049:c120961-120695 [Yersinia kristensenii]
MEIDNRARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT158583 NZ_CP069692:c218450-218387 [Escherichia coli H20]
GTCTAGATGCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7TB89

Antitoxin

Source ID Structure

References