Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 4481985..4482954 Replicon chromosome
Accession NZ_CP054048
Organism Yersinia massiliensis strain 2011N-4075

Toxin (Protein)


Gene name - Uniprot ID A0A0T9TXD8
Locus tag HRD68_RS21250 Protein ID WP_050081128.1
Coordinates 4482496..4482954 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0T9TWM5
Locus tag HRD68_RS21245 Protein ID WP_050081127.1
Coordinates 4481985..4482431 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD68_RS21225 4477597..4478313 + 717 WP_098904506.1 murein tripeptide amidase MpaA -
HRD68_RS21230 4478318..4479289 - 972 WP_057649458.1 L-Ala-D/L-Glu epimerase -
HRD68_RS21235 4479444..4479947 + 504 WP_019209936.1 thiol peroxidase -
HRD68_RS21240 4480089..4481666 - 1578 WP_050081126.1 transcriptional regulator TyrR -
HRD68_RS21245 4481985..4482431 + 447 WP_050081127.1 DUF2384 domain-containing protein Antitoxin
HRD68_RS21250 4482496..4482954 + 459 WP_050081128.1 RES family NAD+ phosphorylase Toxin
HRD68_RS21255 4482981..4484042 - 1062 WP_050081129.1 YcjF family protein -
HRD68_RS21260 4484039..4485436 - 1398 WP_050081130.1 YcjX family protein -
HRD68_RS21265 4485417..4485656 - 240 WP_019209930.1 phage shock protein PspD -
HRD68_RS21270 4485714..4486088 - 375 WP_050285589.1 envelope stress response membrane protein PspC -
HRD68_RS21275 4486088..4486315 - 228 WP_050285588.1 envelope stress response membrane protein PspB -
HRD68_RS21280 4486433..4487098 - 666 WP_050285587.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(36-90)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17297.66 Da        Isoelectric Point: 5.1578

>T158582 WP_050081128.1 NZ_CP054048:4482496-4482954 [Yersinia massiliensis]
MKLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHSAIYLASSVSLAMLETLAHIQDSSTLSEFELFQIEIDDNNIMLLHPT
DWPIDWRNDPAPATTMDVGTEWLESESSVGLLVPSTLVPSENNMLVNPRHKDFQAYLNSVKPLPFSFDPRLK

Download         Length: 459 bp

>T158582 NZ_CP069692:218016-218123 [Escherichia coli H20]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16233.65 Da        Isoelectric Point: 9.1260

>AT158582 WP_050081127.1 NZ_CP054048:4481985-4482431 [Yersinia massiliensis]
MRAYHPTPTAKTGALWREIGLPASRGTILVDSIKLGFSVDVIDSIHLWAAIPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Download         Length: 447 bp

>AT158582 NZ_CP069692:c217959-217904 [Escherichia coli H20]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9TXD8

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9TWM5

References