Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2953834..2954506 Replicon chromosome
Accession NZ_CP054048
Organism Yersinia massiliensis strain 2011N-4075

Toxin (Protein)


Gene name cptA Uniprot ID A0A0T9UGW4
Locus tag HRD68_RS14145 Protein ID WP_050082213.1
Coordinates 2954081..2954506 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0T9UGT3
Locus tag HRD68_RS14140 Protein ID WP_019211617.1
Coordinates 2953834..2954100 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD68_RS14125 2950822..2951571 + 750 WP_050286433.1 SDR family oxidoreductase -
HRD68_RS14130 2951816..2952508 + 693 WP_050082335.1 hemolysin III family protein -
HRD68_RS14135 2952593..2953582 - 990 WP_108087409.1 tRNA-modifying protein YgfZ -
HRD68_RS14140 2953834..2954100 + 267 WP_019211617.1 FAD assembly factor SdhE Antitoxin
HRD68_RS14145 2954081..2954506 + 426 WP_050082213.1 protein YgfX Toxin
HRD68_RS14150 2954506..2955204 + 699 WP_050286436.1 two-component system response regulator CreB -
HRD68_RS14155 2955243..2956670 + 1428 WP_050286437.1 two-component system sensor histidine kinase CreC -
HRD68_RS14160 2956762..2958186 + 1425 WP_050082216.1 cell envelope integrity protein CreD -
HRD68_RS14165 2958277..2958795 - 519 WP_050286440.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16527.43 Da        Isoelectric Point: 9.4189

>T158571 WP_050082213.1 NZ_CP054048:2954081-2954506 [Yersinia massiliensis]
VAQWRCDLRISWHTQLFSLLTHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNVVLWKRL
EWIVVKQPWMTRYGVLLRLRQANSRSTCKRLWLAADSMSEDEWRQLCLLLRHSFDADEGHT

Download         Length: 426 bp

>T158571 NZ_CP069677:4027635-4027913 [Escherichia coli O126:H45]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10532.06 Da        Isoelectric Point: 4.6786

>AT158571 WP_019211617.1 NZ_CP054048:2953834-2954100 [Yersinia massiliensis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDGLSDSEKQIFIRLLECDDPDLFNWLMNHGEPQDDELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp

>AT158571 NZ_CP069677:4027372-4027632 [Escherichia coli O126:H45]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UGW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UGT3

References