Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2097307..2097917 Replicon chromosome
Accession NZ_CP054048
Organism Yersinia massiliensis strain 2011N-4075

Toxin (Protein)


Gene name doc Uniprot ID A0A0T9UYD5
Locus tag HRD68_RS10340 Protein ID WP_050083383.1
Coordinates 2097307..2097699 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0T9UY83
Locus tag HRD68_RS10345 Protein ID WP_049610050.1
Coordinates 2097696..2097917 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD68_RS10315 2092529..2092714 + 186 WP_049610039.1 hypothetical protein -
HRD68_RS10320 2092920..2094068 + 1149 WP_050083387.1 pectate lyase -
HRD68_RS10325 2094147..2094326 - 180 Protein_1783 FKBP-type peptidyl-prolyl cis-trans isomerase -
HRD68_RS10330 2094357..2095967 - 1611 WP_108087239.1 FAD-NAD(P)-binding protein -
HRD68_RS10335 2096609..2097145 - 537 WP_098905050.1 cysteine hydrolase -
HRD68_RS10340 2097307..2097699 - 393 WP_050083383.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HRD68_RS10345 2097696..2097917 - 222 WP_049610050.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HRD68_RS10350 2098167..2099030 - 864 WP_050287365.1 YicC family protein -
HRD68_RS10355 2099160..2099876 + 717 WP_004705100.1 ribonuclease PH -
HRD68_RS10360 2099988..2100635 + 648 WP_108087240.1 orotate phosphoribosyltransferase -
HRD68_RS10365 2101119..2102414 + 1296 WP_108087241.1 dicarboxylate/amino acid:cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14813.78 Da        Isoelectric Point: 6.9895

>T158570 WP_050083383.1 NZ_CP054048:c2097699-2097307 [Yersinia massiliensis]
MMWISAQEVIAFHDRILQRLPGVTGIPDPGRAEALIYRVQNRTHYEGVTDVFELGATYWVAIARGHIFNDGNKRTAFFVT
MAFLYRNGIRIRDTDNSLENLTVAAATGEKTVDQLSQHLRDLVEHTNQIR

Download         Length: 393 bp

>T158570 NZ_CP069677:3809625-3810167 [Escherichia coli O126:H45]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8135.99 Da        Isoelectric Point: 5.5675

>AT158570 WP_049610050.1 NZ_CP054048:c2097917-2097696 [Yersinia massiliensis]
MRTYTSTQARANISEVLDAATHGEPVEITRRDGSSAVVISKAEFETYQNAKLDAEFDVIMQRHGHTVEALTNR

Download         Length: 222 bp

>AT158570 NZ_CP069677:3809330-3809641 [Escherichia coli O126:H45]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
TGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9UYD5

Antitoxin

Source ID Structure
AlphaFold DB A0A0T9UY83

References