Detailed information of TA system TA158568

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 1237874..1238610
• Replicon: chromosome
• Accession: NZ_CP054048
• Organism: Yersinia massiliensis strain 2011N-4075

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: HRD68_RS06530
• Protein ID: WP_172986865.1
• Coordinates: 1238239..1238610 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: HRD68_RS06525
• Protein ID: WP_172986864.1
• Coordinates: 1237874..1238242 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD68_RS06520	1233712..1237213	-	3502	Protein_1060	DNA helicase	-
HRD68_RS06525	1237874..1238242	-	369	WP_172986864.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HRD68_RS06530	1238239..1238610	-	372	WP_172986865.1	TA system toxin CbtA family protein	Toxin
HRD68_RS06535	1238702..1239133	-	432	WP_172986866.1	antirestriction protein	-
HRD68_RS06540	1239490..1240311	-	822	WP_172986867.1	DUF945 domain-containing protein	-
HRD68_RS06545	1240386..1240832	-	447	WP_172986868.1	hypothetical protein	-
HRD68_RS06550	1241055..1242323	-	1269	WP_172986869.1	hypothetical protein	-
HRD68_RS06555	1242343..1242780	-	438	WP_115027090.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1231910..1244446	12536

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (9-101)

Antitoxin

• Antitoxin CbeA (10-108)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13654.75 Da
• Isoelectric Point: 7.3983

>T158568 WP_172986865.1 NZ_CP054048:c1238610-1238239 [Yersinia massiliensis]
MKPLVTAQGALPVPAIYQRLLTFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINTLVEKYALVRIGRNGFSALAQ
DPMLSKGDIVRARQAVGLWRAHFPPTLLYPTESLNPIPQRPLT

Nucleotide

• Length: 372 bp

>T158568 NZ_CP069677:c2808347-2808244 [Escherichia coli O126:H45]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13314.12 Da
• Isoelectric Point: 5.9583

>AT158568 WP_172986864.1 NZ_CP054048:c1238242-1237874 [Yersinia massiliensis]
MNNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSLEATQALDAAFPMLITKLESQLLSGALDPRRQQG
ITVRHGEFVCDADTLGSHGYVYIVVYQELSLLLSEGGGPPDV

Nucleotide

• Length: 369 bp

>AT158568 NZ_CP069677:2808206-2808477 [Escherichia coli O126:H45]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGTAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT