Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 3601893..3602901 Replicon chromosome
Accession NZ_CP054043
Organism Yersinia mollaretii ATCC 43969

Toxin (Protein)


Gene name - Uniprot ID A0A7D4PD68
Locus tag HRD69_RS16045 Protein ID WP_004874286.1
Coordinates 3602443..3602901 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0U1I0M0
Locus tag HRD69_RS16040 Protein ID WP_004874287.1
Coordinates 3601893..3602339 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD69_RS16020 3597535..3598242 + 708 WP_032813606.1 murein tripeptide amidase MpaA -
HRD69_RS16025 3598239..3599210 - 972 WP_032813587.1 L-Ala-D/L-Glu epimerase -
HRD69_RS16030 3599364..3599867 + 504 WP_032813585.1 thiol peroxidase -
HRD69_RS16035 3599996..3601573 - 1578 WP_004874288.1 transcriptional regulator TyrR -
HRD69_RS16040 3601893..3602339 + 447 WP_004874287.1 DUF2384 domain-containing protein Antitoxin
HRD69_RS16045 3602443..3602901 + 459 WP_004874286.1 RES family NAD+ phosphorylase Toxin
HRD69_RS16050 3602930..3603991 - 1062 WP_032813583.1 YcjF family protein -
HRD69_RS16055 3603988..3605385 - 1398 WP_032813581.1 YcjX family protein -
HRD69_RS16060 3605366..3605605 - 240 WP_032813579.1 phage shock protein PspD -
HRD69_RS16065 3605651..3606025 - 375 WP_004874282.1 envelope stress response membrane protein PspC -
HRD69_RS16070 3606025..3606252 - 228 WP_032813577.1 envelope stress response membrane protein PspB -
HRD69_RS16075 3606352..3607017 - 666 WP_004874281.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-147)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(36-90)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 17318.84 Da        Isoelectric Point: 4.9093

>T158560 WP_004874286.1 NZ_CP054043:3602443-3602901 [Yersinia mollaretii ATCC 43969]
MMLYRIVMRRYLASTWTGYGAEIYGGRWNHKGHAALYLASSVSLAMLETLVHIQDSSTLSEFELFQIEIDDSQIMLLQRP
DWPIDWRSDPAPAATMDLGTEWLESESSVGLLVPSTLVPSENNMLVNPRHKEFQLCLNSVKPLSFSFDPRLK

Download         Length: 459 bp

>T158560 NZ_CP069677:963024-963431 [Escherichia coli O126:H45]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16221.66 Da        Isoelectric Point: 9.1260

>AT158560 WP_004874287.1 NZ_CP054043:3601893-3602339 [Yersinia mollaretii ATCC 43969]
MRAYHPAPATKAGALWREIGLPASRGTILVDSIKLGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFSGDKGKAITWMSTPIKGLGHRSPDSLLETETGALEVCDLIGRLEHGVFS

Download         Length: 447 bp

>AT158560 NZ_CP069677:962777-963043 [Escherichia coli O126:H45]
ATGGACATTAATAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D4PD68

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1I0M0

References