Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2779423..2780033 Replicon chromosome
Accession NZ_CP054043
Organism Yersinia mollaretii ATCC 43969

Toxin (Protein)


Gene name doc Uniprot ID A0A7D4U3F2
Locus tag HRD69_RS12215 Protein ID WP_032814502.1
Coordinates 2779641..2780033 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0U1KGJ7
Locus tag HRD69_RS12210 Protein ID WP_032814504.1
Coordinates 2779423..2779644 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD69_RS12190 2775568..2775939 + 372 WP_032814511.1 hypothetical protein -
HRD69_RS12195 2776007..2778067 + 2061 WP_004875296.1 thioredoxin family protein -
HRD69_RS12200 2778064..2778789 + 726 WP_032814508.1 DsbA family protein -
HRD69_RS12205 2778786..2779286 + 501 WP_032814506.1 protein disulfide oxidoreductase -
HRD69_RS12210 2779423..2779644 + 222 WP_032814504.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HRD69_RS12215 2779641..2780033 + 393 WP_032814502.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HRD69_RS12220 2780103..2780996 - 894 WP_004875292.1 DMT family transporter -
HRD69_RS12225 2781137..2781922 + 786 WP_004875291.1 helix-turn-helix transcriptional regulator -
HRD69_RS12230 2782261..2783394 + 1134 WP_004875290.1 4-phosphoerythronate dehydrogenase PdxB -
HRD69_RS12235 2783545..2784555 + 1011 WP_032814500.1 aspartate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14764.77 Da        Isoelectric Point: 6.3283

>T158551 WP_032814502.1 NZ_CP054043:2779641-2780033 [Yersinia mollaretii ATCC 43969]
MMWISAQEVIAFHDRILQCFPGVAGIPEPGRAEALIYRVQNRAHYEGVTDIFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGLHIRNNDEALENLTVEAATGEKTVAQLAHYLRESVDDIAPRR

Download         Length: 393 bp

>T158551 NZ_CP069669:22239-22487 [Escherichia coli O89m:H9]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8093.03 Da        Isoelectric Point: 5.5589

>AT158551 WP_032814504.1 NZ_CP054043:2779423-2779644 [Yersinia mollaretii ATCC 43969]
MRTYTSTQARANISEVLDAATHGEPIEITRRDGSAAVVISKAEFEAYQNAKLDAEFDLMMQRHGHTLAALTDR

Download         Length: 222 bp

>AT158551 NZ_CP069669:22484-22831 [Escherichia coli O89m:H9]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D4U3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1KGJ7

References