Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2428254..2428873 Replicon chromosome
Accession NZ_CP054043
Organism Yersinia mollaretii ATCC 43969

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag HRD69_RS10725 Protein ID WP_002208622.1
Coordinates 2428254..2428457 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0U1K7N3
Locus tag HRD69_RS10730 Protein ID WP_004873431.1
Coordinates 2428505..2428873 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD69_RS10695 2423545..2423883 + 339 WP_002208627.1 P-II family nitrogen regulator -
HRD69_RS10700 2423923..2425212 + 1290 WP_032813019.1 ammonium transporter AmtB -
HRD69_RS10705 2425359..2426219 - 861 WP_004873434.1 acyl-CoA thioesterase II -
HRD69_RS10710 2426476..2427003 + 528 WP_004873433.1 YbaY family lipoprotein -
HRD69_RS10715 2427055..2427444 - 390 WP_032812962.1 MGMT family protein -
HRD69_RS10725 2428254..2428457 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
HRD69_RS10730 2428505..2428873 - 369 WP_004873431.1 Hha toxicity modulator TomB Antitoxin
HRD69_RS10735 2429032..2429385 - 354 WP_032812960.1 hypothetical protein -
HRD69_RS10740 2430175..2430912 + 738 WP_050413161.1 ABC transporter ATP-binding protein -
HRD69_RS10745 2430909..2431766 + 858 WP_032812959.1 metal ABC transporter permease -
HRD69_RS10750 2431795..2432673 + 879 WP_004873426.1 metal ABC transporter substrate-binding protein -
HRD69_RS10755 2432831..2432974 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
HRD69_RS10760 2432990..2433250 - 261 WP_032812957.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T158550 WP_002208622.1 NZ_CP054043:c2428457-2428254 [Yersinia mollaretii ATCC 43969]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T158550 NZ_CP069669:20275-20526 [Escherichia coli O89m:H9]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCTGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14253.00 Da        Isoelectric Point: 4.4314

>AT158550 WP_004873431.1 NZ_CP054043:c2428873-2428505 [Yersinia mollaretii ATCC 43969]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWVNDPTAAVNLQLNDLIEHIASFVMSFKIKYPDDGDFSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKERLFRLFSGEYICTLMKT

Download         Length: 369 bp

>AT158550 NZ_CP069669:20513-20740 [Escherichia coli O89m:H9]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1K7N3

References