Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1329278..1329921 Replicon chromosome
Accession NZ_CP054043
Organism Yersinia mollaretii ATCC 43969

Toxin (Protein)


Gene name vagD Uniprot ID A0A7D4P482
Locus tag HRD69_RS05820 Protein ID WP_072099547.1
Coordinates 1329502..1329921 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A7D4P724
Locus tag HRD69_RS05815 Protein ID WP_004876171.1
Coordinates 1329278..1329505 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD69_RS05790 1324561..1325724 + 1164 WP_004876176.1 mannitol-1-phosphate 5-dehydrogenase -
HRD69_RS05795 1325822..1326376 + 555 WP_004876175.1 MltR family transcriptional regulator -
HRD69_RS05800 1326378..1326986 - 609 WP_032815081.1 LysE family translocator -
HRD69_RS05805 1327149..1328630 + 1482 WP_032815071.1 PLP-dependent aminotransferase family protein -
HRD69_RS05810 1328724..1329080 + 357 WP_004876172.1 YibL family ribosome-associated protein -
HRD69_RS05815 1329278..1329505 + 228 WP_004876171.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HRD69_RS05820 1329502..1329921 + 420 WP_072099547.1 type II toxin-antitoxin system VapC family toxin Toxin
HRD69_RS05825 1330092..1330766 - 675 WP_004876169.1 6-N-hydroxylaminopurine resistance protein -
HRD69_RS05830 1330865..1332814 - 1950 WP_004876168.1 methyl-accepting chemotaxis protein -
HRD69_RS05835 1333137..1333760 - 624 WP_032815070.1 superoxide dismutase [Mn] -
HRD69_RS05840 1333886..1334740 - 855 WP_032815068.1 formate dehydrogenase accessory sulfurtransferase FdhD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-131)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15601.22 Da        Isoelectric Point: 9.0596

>T158549 WP_072099547.1 NZ_CP054043:1329502-1329921 [Yersinia mollaretii ATCC 43969]
MIKKIYMLDTNICSFIMRERPAEIIIKLQQCIEHQNKIVVSAITYSEMRFGAIGKKASPKHTYLVDEFVKRLDAIFPWDV
AAIDATTNIKIDLAKQGTPIGGNDAAIAGHAISTGAILVTNNVREFERVKKLRIEDWAN

Download         Length: 420 bp

>T158549 NZ_CP069668:2043-2321 [Escherichia coli O89m:H9]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8799.95 Da        Isoelectric Point: 4.2188

>AT158549 WP_004876171.1 NZ_CP054043:1329278-1329505 [Yersinia mollaretii ATCC 43969]
MRTVSIFKNGQNRAIRLPKDMDFEGATELEIIKEGDNIILRPIRPTWVSFMDEDKADDDFLAERQDIIEEGRFEL

Download         Length: 228 bp

>AT158549 NZ_CP069668:1774-2043 [Escherichia coli O89m:H9]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTTCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D4P482

Antitoxin

Source ID Structure
AlphaFold DB A0A7D4P724

References