Detailed information of TA system TA158548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 1027059..1027660
• Replicon: chromosome
• Accession: NZ_CP054043
• Organism: Yersinia mollaretii ATCC 43969

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: HRD69_RS04495
• Protein ID: WP_145569604.1
• Coordinates: 1027059..1027415 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: A0A7D4P9U2
• Locus tag: HRD69_RS04500
• Protein ID: WP_004876962.1
• Coordinates: 1027409..1027660 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HRD69_RS04475	1022075..1022449	-	375	WP_004876970.1	antitermination protein	-
HRD69_RS04480	1022762..1024240	-	1479	WP_032815311.1	ketol-acid reductoisomerase	-
HRD69_RS04485	1024417..1025298	+	882	WP_004876966.1	HTH-type transcriptional activator IlvY	-
HRD69_RS04490	1025333..1026652	-	1320	WP_004876964.1	hypothetical protein	-
HRD69_RS04495	1027059..1027415	-	357	WP_145569604.1	type II toxin-antitoxin system ChpB family toxin	Toxin
HRD69_RS04500	1027409..1027660	-	252	WP_004876962.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HRD69_RS04505	1028017..1028901	+	885	WP_172984601.1	Rpn family recombination-promoting nuclease/putative transposase	-
HRD69_RS04510	1029121..1029993	+	873	WP_172984602.1	Rpn family recombination-promoting nuclease/putative transposase	-
HRD69_RS04515	1030022..1030276	+	255	Protein_869	Rpn family recombination-promoting nuclease/putative transposase	-
HRD69_RS04520	1030319..1030435	+	117	Protein_870	phage tail protein	-
HRD69_RS04525	1030536..1031327	-	792	WP_004877660.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-107)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 12838.91 Da
• Isoelectric Point: 8.0166

>T158548 WP_145569604.1 NZ_CP054043:c1027415-1027059 [Yersinia mollaretii ATCC 43969]
MVKRKQGWDRGDIVLVDFNPAIGSEQRDARPALVLTKKLFNNLGMALVAPITQGGNYARHAGFTVSLSGTGCATQGVVLL
NQARMIDLMARNARFVEPLDEVVINDALLKFATLVEID

Nucleotide

• Length: 357 bp

>T158548 NZ_CP069667:21331-21747 [Escherichia coli O89m:H9]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.47 Da
• Isoelectric Point: 4.9859

>AT158548 WP_004876962.1 NZ_CP054043:c1027660-1027409 [Yersinia mollaretii ATCC 43969]
MTIAIKKWGNSSGVVLPSLLLKKLGVTTGQHLDAEIKNGSLILTPTQRRYTLEELVAQCDKNAPMMAEEDVWGNDAPTGN
EIW

Nucleotide

• Length: 252 bp

>AT158548 NZ_CP069667:21104-21334 [Escherichia coli O89m:H9]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7D4P9U2