Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 303948..304648 Replicon chromosome
Accession NZ_CP054043
Organism Yersinia mollaretii ATCC 43969

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7D4T0K6
Locus tag HRD69_RS01365 Protein ID WP_004876044.1
Coordinates 303948..304304 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A7D4TKP3
Locus tag HRD69_RS01370 Protein ID WP_004876043.1
Coordinates 304316..304648 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD69_RS01340 299929..300750 + 822 WP_004876051.1 DUF945 domain-containing protein -
HRD69_RS01345 301475..302026 + 552 WP_004876048.1 DUF4339 domain-containing protein -
HRD69_RS01350 302629..303060 + 432 WP_032815008.1 antirestriction protein -
HRD69_RS01355 303093..303566 + 474 WP_004876046.1 DNA repair protein RadC -
HRD69_RS01360 303560..303892 + 333 WP_050413212.1 hypothetical protein -
HRD69_RS01365 303948..304304 + 357 WP_004876044.1 TA system toxin CbtA family protein Toxin
HRD69_RS01370 304316..304648 + 333 WP_004876043.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HRD69_RS01375 304733..305593 + 861 WP_004876042.1 DUF4942 domain-containing protein -
HRD69_RS01380 305872..307095 - 1224 WP_004876041.1 pyridoxal phosphate-dependent aminotransferase -
HRD69_RS01385 307112..308797 - 1686 WP_004876040.1 L-2,4-diaminobutyrate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 290662..319040 28378


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13097.05 Da        Isoelectric Point: 6.2134

>T158547 WP_004876044.1 NZ_CP054043:303948-304304 [Yersinia mollaretii ATCC 43969]
MKPRPTAQGALPVPVIYQQLLAFLLEHYYGLSLNDTPYHDEQVITQQIEQEISVGDTINALVEKYALVRIGRAGFSALAQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIP

Download         Length: 357 bp

>T158547 NZ_CP069666:c4278199-4278026 [Escherichia coli O89m:H9]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12189.88 Da        Isoelectric Point: 6.8585

>AT158547 WP_004876043.1 NZ_CP054043:304316-304648 [Yersinia mollaretii ATCC 43969]
MNNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSLEATQSLDTVFPALITKLESQLLSGQLDPRRQQC
LTVRLGGFVCDADTLGSHGYVYIAVYQELS

Download         Length: 333 bp

>AT158547 NZ_CP069666:c4278523-4278227 [Escherichia coli O89m:H9]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D4T0K6

Antitoxin

Source ID Structure
AlphaFold DB A0A7D4TKP3

References