Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 175097..175772 Replicon chromosome
Accession NZ_CP054043
Organism Yersinia mollaretii ATCC 43969

Toxin (Protein)


Gene name cptA Uniprot ID A0A7D4TKJ7
Locus tag HRD69_RS00785 Protein ID WP_032813753.1
Coordinates 175097..175525 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7D4T4R2
Locus tag HRD69_RS00790 Protein ID WP_004874419.1
Coordinates 175506..175772 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRD69_RS00765 170822..171340 + 519 WP_004874424.1 flavodoxin FldB -
HRD69_RS00770 171399..172826 - 1428 WP_004874423.1 cell envelope integrity protein CreD -
HRD69_RS00775 172919..174346 - 1428 WP_004874422.1 two-component system sensor histidine kinase CreC -
HRD69_RS00780 174402..175100 - 699 WP_032813754.1 two-component system response regulator CreB -
HRD69_RS00785 175097..175525 - 429 WP_032813753.1 protein YgfX Toxin
HRD69_RS00790 175506..175772 - 267 WP_004874419.1 FAD assembly factor SdhE Antitoxin
HRD69_RS00795 176070..177062 + 993 WP_004874418.1 tRNA-modifying protein YgfZ -
HRD69_RS00800 177158..177805 - 648 WP_099466172.1 hemolysin III family protein -
HRD69_RS00805 178060..178809 - 750 WP_004874416.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 16577.45 Da        Isoelectric Point: 10.1162

>T158546 WP_032813753.1 NZ_CP054043:c175525-175097 [Yersinia mollaretii ATCC 43969]
VAQWRCDLRISWHTQLFSLLTHGVLVILTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNVVLWKRL
EWSVVKQPWITRYGVLLSLKQAGHRSTRKRLWLAADSMSEDEWRQLCLLLRHSFDADEGLNR

Download         Length: 429 bp

>T158546 NZ_CP069666:4266426-4266800 [Escherichia coli O89m:H9]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCGC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGAACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.06 Da        Isoelectric Point: 5.1404

>AT158546 WP_004874419.1 NZ_CP054043:c175772-175506 [Yersinia mollaretii ATCC 43969]
MEIDNKSRIHWACRRGMRELDISIMPFFEYEYDGLSDHEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQARN
KARGPVAM

Download         Length: 267 bp

>AT158546 NZ_CP069666:4266005-4266379 [Escherichia coli O89m:H9]
GTGTCAGACACACTCTCCGGGATAACTCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGACTGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D4TKJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A7D4T4R2

References