Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3655078..3655760 Replicon chromosome
Accession NZ_CP054038
Organism Microbacterium hominis strain PA2F3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HQM25_RS16355 Protein ID WP_172991199.1
Coordinates 3655078..3655476 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HQM25_RS16360 Protein ID WP_172991200.1
Coordinates 3655473..3655760 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQM25_RS16340 3651319..3652719 + 1401 WP_172991720.1 MFS transporter -
HQM25_RS16345 3652770..3654305 + 1536 WP_172991197.1 peptide MFS transporter -
HQM25_RS16350 3654316..3655074 - 759 WP_172991198.1 helix-turn-helix domain-containing protein -
HQM25_RS16355 3655078..3655476 - 399 WP_172991199.1 type II toxin-antitoxin system VapC family toxin Toxin
HQM25_RS16360 3655473..3655760 - 288 WP_172991200.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HQM25_RS16365 3655801..3656976 - 1176 WP_172991201.1 thiolase family protein -
HQM25_RS16370 3656978..3657652 - 675 WP_172991202.1 3-oxoacid CoA-transferase subunit B -
HQM25_RS16375 3657649..3658413 - 765 WP_172991203.1 3-oxoacid CoA-transferase subunit A -
HQM25_RS16380 3658512..3658907 - 396 WP_172991204.1 4-carboxymuconolactone decarboxylase -
HQM25_RS16385 3658904..3659695 - 792 WP_172991205.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(2-94)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13927.49 Da        Isoelectric Point: 4.0938

>T158544 WP_172991199.1 NZ_CP054038:c3655476-3655078 [Microbacterium hominis]
VIVDTSALIAILQDEDSAADLAELLLEQGGAISAVTLLEARIVALARGGASAVRRVDDMVAQFSLDIAPFDARQSDVAAT
AYRDYGKGSGHPARLNFGDTASYALARVQNDSLLYVGDDFSRTDIRPALEDG

Download         Length: 399 bp

>T158544 NZ_CP069666:3582736-3583014 [Escherichia coli O89m:H9]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11153.44 Da        Isoelectric Point: 5.7112

>AT158544 WP_172991200.1 NZ_CP054038:c3655760-3655473 [Microbacterium hominis]
VSLNIKNESVHALVRELAEITGMSQTSAVEDAVRRRLEQLREETPKRRFSPEEEARRRAEIRRIVAQFHEETTPEQREAM
SNHGDWLYDELGLPR

Download         Length: 288 bp

>AT158544 NZ_CP069666:3582473-3582733 [Escherichia coli O89m:H9]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References