Detailed information of TA system TA158536

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 599337..599869
• Replicon: plasmid pPR13E01
• Accession: NZ_CP054032
• Organism: Rhizobium indicum strain JKLM 13E

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FE844_RS26735
• Protein ID: WP_138331113.1
• Coordinates: 599337..599630 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A559THZ3
• Locus tag: FE844_RS26740
• Protein ID: WP_028739446.1
• Coordinates: 599627..599869 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE844_RS26715	594436..596034	+	1599	WP_138331115.1	MFS transporter	-
FE844_RS26720	596103..597083	+	981	WP_138331114.1	alpha/beta hydrolase	-
FE844_RS26725	597214..598107	-	894	WP_138331201.1	AraC family transcriptional regulator	-
FE844_RS26730	598408..599241	+	834	WP_138331200.1	AraC family transcriptional regulator	-
FE844_RS26735	599337..599630	-	294	WP_138331113.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FE844_RS26740	599627..599869	-	243	WP_028739446.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
FE844_RS26745	600717..601745	-	1029	WP_138331112.1	PHB depolymerase family esterase	-
FE844_RS26750	601742..602197	-	456	WP_138331111.1	NUDIX hydrolase	-
FE844_RS26755	602326..603789	+	1464	WP_138331110.1	CHAD domain-containing protein	-
FE844_RS26760	603874..604329	+	456	WP_138331109.1	NUDIX hydrolase	-
FE844_RS26765	604412..604558	-	147	Protein_566	DUF3606 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..1207524	1207524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11259.73 Da
• Isoelectric Point: 4.7466

>T158536 WP_138331113.1 NZ_CP054032:c599630-599337 [Rhizobium indicum]
MSFKLSAEAEEDIIAIAEQGVRMFGAGQANRYHDELFTLFDLIAVNPRIARERDEIDPPVRIHPFKAHVIVYRIEDDETI
FVIRIRHAHEDWASESI

Nucleotide

• Length: 294 bp

>T158536 NZ_CP069666:1955145-1955248 [Escherichia coli O89m:H9]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8854.00 Da
• Isoelectric Point: 9.7765

>AT158536 WP_028739446.1 NZ_CP054032:c599869-599627 [Rhizobium indicum]
MATMNVSLPGPMKDWVEAQARTGRYSNASDYVRDLIRRDQTRNDKIAAMQSFVEAGLQSGVGIRSKDELFAEAMARASKS

Nucleotide

• Length: 243 bp

>AT158536 NZ_CP069666:c1955286-1955015 [Escherichia coli O89m:H9]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A559THZ3