Detailed information of TA system TA158533

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4002497..4003128
• Replicon: chromosome
• Accession: NZ_CP054031
• Organism: Rhizobium indicum strain JKLM 13E

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FE844_RS19390
• Protein ID: WP_138332267.1
• Coordinates: 4002497..4002889 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A2A6HZU6
• Locus tag: FE844_RS19395
• Protein ID: WP_018495663.1
• Coordinates: 4002886..4003128 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE844_RS19365	3998069..3998833	-	765	WP_138332262.1	SDR family oxidoreductase	-
FE844_RS19370	3998960..3999865	+	906	WP_138332263.1	LysR family transcriptional regulator	-
FE844_RS19375	3999867..4000745	-	879	WP_138332264.1	LysR family transcriptional regulator	-
FE844_RS19380	4000836..4002086	+	1251	WP_138332265.1	MFS transporter	-
FE844_RS19385	4002083..4002469	+	387	WP_138332266.1	VOC family protein	-
FE844_RS19390	4002497..4002889	-	393	WP_138332267.1	type II toxin-antitoxin system VapC family toxin	Toxin
FE844_RS19395	4002886..4003128	-	243	WP_018495663.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FE844_RS19400	4003182..4004843	-	1662	WP_138332268.1	urocanate hydratase	-
FE844_RS19405	4004862..4005191	-	330	WP_138332269.1	TfoX/Sxy family protein	-
FE844_RS19410	4005196..4006293	-	1098	WP_138332270.1	DUF917 family protein	-
FE844_RS19415	4006274..4007554	-	1281	WP_138332271.1	Zn-dependent hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• SpoVT-AbrB domain (7-44)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14691.89 Da
• Isoelectric Point: 5.7723

>T158533 WP_138332267.1 NZ_CP054031:c4002889-4002497 [Rhizobium indicum]
MKYLLDANAVIALMKVNERLIAELRKHRPQDFALPAIVAHELFYGAYKSLRTDENLARIDALQFNILEFDRNDARKAGEI
RAALQALGTPIGPYDVLIAGQAAARGLILITRSLREFERVADLQTENWED

Nucleotide

• Length: 393 bp

>T158533 NZ_CP069666:957651-957986 [Escherichia coli O89m:H9]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9126.19 Da
• Isoelectric Point: 4.3533

>AT158533 WP_018495663.1 NZ_CP054031:c4003128-4002886 [Rhizobium indicum]
METAKIFWSGRSQAVRLPKEFRFDGDSVTIRRQGRAIILEPISDDWDWLADVAGPVDQDFATAAEEKPAGQERPELDFFK

Nucleotide

• Length: 243 bp

>AT158533 NZ_CP069666:957403-957651 [Escherichia coli O89m:H9]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2A6HZU6