Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1142471..1143045 Replicon plasmid pPR19E01
Accession NZ_CP054028
Organism Rhizobium hidalgonense strain JKLM 19E

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FFM81_RS26595 Protein ID WP_138386559.1
Coordinates 1142471..1142836 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FFM81_RS26600 Protein ID WP_138386560.1
Coordinates 1142830..1143045 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFM81_RS26580 1138909..1140543 - 1635 WP_138386557.1 chaperonin GroEL -
FFM81_RS26585 1140609..1140905 - 297 WP_138386558.1 co-chaperone GroES -
FFM81_RS26590 1141374..1142396 + 1023 Protein_1065 ribosome small subunit-dependent GTPase A -
FFM81_RS26595 1142471..1142836 - 366 WP_138386559.1 type II toxin-antitoxin system VapC family toxin Toxin
FFM81_RS26600 1142830..1143045 - 216 WP_138386560.1 ribbon-helix-helix domain-containing protein Antitoxin
FFM81_RS26605 1143593..1143894 - 302 Protein_1068 type II toxin-antitoxin system RelB/DinJ family antitoxin -
FFM81_RS26610 1143999..1144151 - 153 WP_173883856.1 hypothetical protein -
FFM81_RS26615 1144203..1145006 - 804 WP_138386561.1 DUF1236 domain-containing protein -
FFM81_RS26620 1145103..1145498 - 396 WP_173883857.1 DUF1236 domain-containing protein -
FFM81_RS26625 1145626..1145898 - 273 WP_173883858.1 BON domain-containing protein -
FFM81_RS26630 1146263..1146993 + 731 Protein_1073 PAS domain-containing protein -
FFM81_RS26635 1147457..1147828 + 372 WP_138385690.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB / gmd 1..1610741 1610741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13760.14 Da        Isoelectric Point: 9.5887

>T158531 WP_138386559.1 NZ_CP054028:c1142836-1142471 [Rhizobium hidalgonense]
MVKSLFDTNVLIDYLNAVPQARDELRRYREKSISIITWMEVLVGAKPEVAIGTRAFLAGFAVIAVDNAIAERAVSLRQLH
RIKLPDAIIWATANVHSMLLITRNTKDFPREMPDIRVPYEI

Download         Length: 366 bp

>T158531 NZ_CP069666:710567-710863 [Escherichia coli O89m:H9]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8238.38 Da        Isoelectric Point: 4.7719

>AT158531 WP_138386560.1 NZ_CP054028:c1143045-1142830 [Rhizobium hidalgonense]
MRTLVDIGDPEIKALDRLAQREKMSRAALIRNAINEFLARNNADIEAEAFGLWGDRKIDGLMYQENMRSEW

Download         Length: 216 bp

>AT158531 NZ_CP069666:710865-711260 [Escherichia coli O89m:H9]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References