Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 605288..605823 Replicon plasmid pPR19E01
Accession NZ_CP054028
Organism Rhizobium hidalgonense strain JKLM 19E

Toxin (Protein)


Gene name relE Uniprot ID J0K5H2
Locus tag FFM81_RS24085 Protein ID WP_003572792.1
Coordinates 605288..605563 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J0C0N0
Locus tag FFM81_RS24090 Protein ID WP_003572794.1
Coordinates 605563..605823 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFM81_RS24065 600457..601383 - 927 WP_097534720.1 sugar ABC transporter permease -
FFM81_RS24070 601472..602695 - 1224 WP_003572785.1 sugar ABC transporter substrate-binding protein -
FFM81_RS24075 602746..604068 - 1323 WP_138384433.1 alpha-L-fucosidase -
FFM81_RS24080 604275..605282 + 1008 WP_138384432.1 LacI family transcriptional regulator -
FFM81_RS24085 605288..605563 - 276 WP_003572792.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFM81_RS24090 605563..605823 - 261 WP_003572794.1 ribbon-helix-helix domain-containing protein Antitoxin
FFM81_RS24095 606119..606847 + 729 WP_138384701.1 FadR family transcriptional regulator -
FFM81_RS24100 607118..608131 + 1014 WP_003572798.1 ABC transporter substrate-binding protein -
FFM81_RS24105 608226..609044 + 819 WP_003572799.1 ABC transporter ATP-binding protein -
FFM81_RS24110 609057..609938 + 882 WP_003572801.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB / gmd 1..1610741 1610741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10818.38 Da        Isoelectric Point: 8.4825

>T158530 WP_003572792.1 NZ_CP054028:c605563-605288 [Rhizobium hidalgonense]
MDVKWTNKAISDIARLYDFLSPVDRGAAVRTVQTLTAAPARLIEQPRLGERLEEFDPQEVRRILVGRYEMRYEIQQSTIY
VLRIWHTREDR

Download         Length: 276 bp

>T158530 NZ_CP069666:645992-646306 [Escherichia coli O89m:H9]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9700.91 Da        Isoelectric Point: 4.6263

>AT158530 WP_003572794.1 NZ_CP054028:c605823-605563 [Rhizobium hidalgonense]
METKVLTAHVPLPLAQKVDQLASRLERSRGWIVKQALSAWIDQEEERRRLTLEALADVESGNVVDHQSVQAWADSLDSDE
PISLPR

Download         Length: 261 bp

>AT158530 NZ_CP069666:646303-646719 [Escherichia coli O89m:H9]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6KED9

Antitoxin

Source ID Structure
AlphaFold DB A0A2A6KDC2

References