Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 111640..112247 Replicon plasmid pPR19E01
Accession NZ_CP054028
Organism Rhizobium hidalgonense strain JKLM 19E

Toxin (Protein)


Gene name hicA Uniprot ID J0VFB1
Locus tag FFM81_RS21790 Protein ID WP_003572077.1
Coordinates 111993..112247 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FFM81_RS21785 Protein ID WP_138384597.1
Coordinates 111640..111996 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFM81_RS21765 107079..108122 + 1044 WP_003572068.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
FFM81_RS21770 108277..109368 - 1092 WP_138384599.1 saccharopine dehydrogenase NADP-binding domain-containing protein -
FFM81_RS21775 109460..110056 + 597 WP_003572073.1 TetR/AcrR family transcriptional regulator -
FFM81_RS21780 110375..111436 + 1062 WP_138384598.1 hypothetical protein -
FFM81_RS21785 111640..111996 - 357 WP_138384597.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FFM81_RS21790 111993..112247 - 255 WP_003572077.1 type II toxin-antitoxin system HicA family toxin Toxin
FFM81_RS21795 112982..114976 - 1995 WP_003572078.1 glycosyltransferase -
FFM81_RS21800 114958..116190 - 1233 WP_003572079.1 HlyD family efflux transporter periplasmic adaptor subunit -
FFM81_RS21805 116598..116798 - 201 WP_003572080.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB / htpB / gmd 1..1610741 1610741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9336.70 Da        Isoelectric Point: 9.8124

>T158528 WP_003572077.1 NZ_CP054028:c112247-111993 [Rhizobium hidalgonense]
MNSKQRKTLAAVFKDPVSGTIEWAAIENLLVAAGADLIEGNGSRVKFEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

>T158528 NZ_CP069666:179382-179489 [Escherichia coli O89m:H9]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13302.96 Da        Isoelectric Point: 4.9838

>AT158528 WP_138384597.1 NZ_CP054028:c111996-111640 [Rhizobium hidalgonense]
MNIMTYNGYHARIEFDAEDDVFFGRIAGISDIIGFHGDSVAELKKAFHEAVDDYLETCRKIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHYAEARLPA

Download         Length: 357 bp

>AT158528 NZ_CP069666:c179334-179268 [Escherichia coli O89m:H9]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246TAE7

Antitoxin

Source ID Structure

References