Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 4404909..4405531 Replicon chromosome
Accession NZ_CP054021
Organism Rhizobium indicum strain JKLM 12A2

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FFM53_RS21355 Protein ID WP_138387133.1
Coordinates 4404909..4405268 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A916SBJ0
Locus tag FFM53_RS21360 Protein ID WP_037063579.1
Coordinates 4405268..4405531 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFM53_RS21330 4400684..4400989 - 306 WP_130658211.1 hypothetical protein -
FFM53_RS21335 4401405..4401545 - 141 WP_173883617.1 hypothetical protein -
FFM53_RS21340 4402290..4402658 - 369 WP_138387130.1 DUF488 domain-containing protein -
FFM53_RS21345 4402799..4403455 + 657 WP_138387131.1 fructose-6-phosphate aldolase -
FFM53_RS21350 4403932..4404753 + 822 WP_138387132.1 universal stress protein -
FFM53_RS21355 4404909..4405268 - 360 WP_138387133.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FFM53_RS21360 4405268..4405531 - 264 WP_037063579.1 PbsX family transcriptional regulator Antitoxin
FFM53_RS21365 4406175..4406930 + 756 WP_138387134.1 IS1595 family transposase -
FFM53_RS21370 4406927..4407388 - 462 WP_138387135.1 hypothetical protein -
FFM53_RS21375 4407598..4408245 - 648 WP_197729628.1 uracil-DNA glycosylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4386771..4436299 49528


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-113)

Antitoxin

SpoVT-AbrB domain

(17-52)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 12889.05 Da        Isoelectric Point: 8.3020

>T158525 WP_138387133.1 NZ_CP054021:c4405268-4404909 [Rhizobium indicum]
MVRSNIPKRGDVFLVDLNPVVGNEMRDDHRCVVITPREINLVGMCLTVPITTGGAFTRKAGLAVNISGHKTTGVALCNQV
RALDILERVKQKTAKHVDTLDASTIDEIVARVVSMIDPA

Download         Length: 360 bp

>T158525 NZ_CP069660:2043-2321 [Escherichia coli O89m:H10]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
TGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9201.63 Da        Isoelectric Point: 8.6165

>AT158525 WP_037063579.1 NZ_CP054021:c4405531-4405268 [Rhizobium indicum]
MSNTAKIRRQGGATVFSIPPALLKMLGVEVGTELTLVVNNGSLVATPKQGKKRYTLAELLEGADEMAALNKEAASWNVST
PVGNEVF

Download         Length: 264 bp

>AT158525 NZ_CP069660:1774-2043 [Escherichia coli O89m:H10]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTTCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGGGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References