Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1148365..1148875 Replicon chromosome
Accession NZ_CP054017
Organism Staphylococcus warneri strain FDAARGOS_754

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag FOC62_RS05865 Protein ID WP_002451637.1
Coordinates 1148365..1148571 (-) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag FOC62_RS05870 Protein ID WP_002451638.1
Coordinates 1148582..1148875 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC62_RS05845 1143954..1145315 - 1362 WP_002451633.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
FOC62_RS05850 1145331..1146401 - 1071 WP_002451634.1 D-alanine--D-alanine ligase -
FOC62_RS05855 1146760..1147950 + 1191 WP_002451635.1 rod shape-determining protein RodA -
FOC62_RS05860 1148088..1148225 - 138 WP_002451636.1 hypothetical protein -
FOC62_RS05865 1148365..1148571 - 207 WP_002451637.1 heavy-metal-associated domain-containing protein Toxin
FOC62_RS05870 1148582..1148875 - 294 WP_002451638.1 copper-sensing transcriptional repressor CsoR Antitoxin
FOC62_RS05875 1149064..1150548 + 1485 WP_002451639.1 cardiolipin synthase -
FOC62_RS05880 1150678..1151322 + 645 WP_002451640.1 HD domain-containing protein -
FOC62_RS05885 1151362..1152231 - 870 WP_002451641.1 membrane protein insertase YidC -
FOC62_RS05890 1152320..1152961 - 642 WP_002451642.1 thiamine phosphate synthase -
FOC62_RS05895 1152962..1153753 - 792 WP_002451643.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7686.62 Da        Isoelectric Point: 3.8774

>T158522 WP_002451637.1 NZ_CP054017:c1148571-1148365 [Staphylococcus warneri]
VQQKIVYTAGIETQEQSESVKNLLTEMIGVYQVEIDINTGNISIEFETPANLNSIEKEIYDAGYKVLY

Download         Length: 207 bp

>T158522 NZ_CP069657:c4166084-4165797 [Escherichia coli O89m:H10]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11159.63 Da        Isoelectric Point: 6.3270

>AT158522 WP_002451638.1 NZ_CP054017:c1148875-1148582 [Staphylococcus warneri]
VTEQDHAHHSEQSKANLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIAEKVNQGHQ
EEAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT158522 NZ_CP069657:c4165810-4165508 [Escherichia coli O89m:H10]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References