Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1137224..1137753 Replicon chromosome
Accession NZ_CP054017
Organism Staphylococcus warneri strain FDAARGOS_754

Toxin (Protein)


Gene name mazF Uniprot ID A0A2T4PXE7
Locus tag FOC62_RS05805 Protein ID WP_002451625.1
Coordinates 1137224..1137586 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2T4PXF4
Locus tag FOC62_RS05810 Protein ID WP_002451626.1
Coordinates 1137583..1137753 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC62_RS05785 1134249..1135019 - 771 WP_002451621.1 RNA polymerase sigma factor SigB -
FOC62_RS05790 1134994..1135473 - 480 WP_002451622.1 anti-sigma B factor RsbW -
FOC62_RS05795 1135475..1135801 - 327 WP_002451623.1 anti-sigma factor antagonist -
FOC62_RS05800 1135896..1136897 - 1002 WP_002451624.1 PP2C family protein-serine/threonine phosphatase -
FOC62_RS05805 1137224..1137586 - 363 WP_002451625.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FOC62_RS05810 1137583..1137753 - 171 WP_002451626.1 hypothetical protein Antitoxin
FOC62_RS05815 1137845..1138993 - 1149 WP_002451627.1 alanine racemase -
FOC62_RS05820 1139045..1139419 - 375 WP_002451628.1 holo-ACP synthase -
FOC62_RS05825 1139452..1139949 - 498 WP_002451629.1 PH domain-containing protein -
FOC62_RS05830 1139936..1141462 - 1527 WP_002451630.1 PH domain-containing protein -
FOC62_RS05835 1141455..1141928 - 474 WP_002451631.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13562.68 Da        Isoelectric Point: 9.9783

>T158521 WP_002451625.1 NZ_CP054017:c1137586-1137224 [Staphylococcus warneri]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKNRLKEKLTYLSDNKMKEVDYALDISLGLHNFNHSKT

Download         Length: 363 bp

>T158521 NZ_CP069657:3783967-3784245 [Escherichia coli O89m:H10]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6300.94 Da        Isoelectric Point: 3.8309

>AT158521 WP_002451626.1 NZ_CP054017:c1137753-1137583 [Staphylococcus warneri]
MLSFNQNRSYSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNAKNE

Download         Length: 171 bp

>AT158521 NZ_CP069657:3783704-3783964 [Escherichia coli O89m:H10]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T4PXE7

Antitoxin

Source ID Structure
AlphaFold DB A0A2T4PXF4

References