Detailed information of TA system TA158516

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 34780..35242
• Replicon: chromosome
• Accession: NZ_CP054017
• Organism: Staphylococcus warneri strain FDAARGOS_754

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: -
• Locus tag: FOC62_RS00400
• Protein ID: WP_002450868.1
• Coordinates: 34780..34965 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: FOC62_RS00405
• Protein ID: WP_002450867.1
• Coordinates: 34985..35242 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC62_RS00355	29896..30261	+	366	WP_002450877.1	hypothetical protein	-
FOC62_RS00360	30581..30781	+	201	WP_002450876.1	cold-shock protein	-
FOC62_RS00365	30956..31189	-	234	WP_002450875.1	hypothetical protein	-
FOC62_RS00370	31418..31657	-	240	WP_002450874.1	hypothetical protein	-
FOC62_RS00375	32123..32338	-	216	WP_002450873.1	hypothetical protein	-
FOC62_RS00380	32416..32700	-	285	WP_002450872.1	hypothetical protein	-
FOC62_RS00385	32790..33542	-	753	WP_002450871.1	poly-gamma-glutamate hydrolase family protein	-
FOC62_RS00390	33806..34039	+	234	WP_002450870.1	hypothetical protein	-
FOC62_RS00395	34099..34680	-	582	WP_037551972.1	orthopoxovirus protein, PF05708 family	-
FOC62_RS00400	34780..34965	-	186	WP_002450868.1	hypothetical protein	Toxin
FOC62_RS00405	34985..35242	-	258	WP_002450867.1	hypothetical protein	Antitoxin
FOC62_RS00410	35497..35700	+	204	WP_002450866.1	sterile alpha motif-like domain-containing protein	-
FOC62_RS00415	35692..35925	-	234	WP_002450865.1	hypothetical protein	-
FOC62_RS00420	36126..36716	+	591	WP_002450864.1	histidine phosphatase family protein	-
FOC62_RS00425	36846..37340	-	495	WP_002450863.1	GNAT family N-acetyltransferase	-
FOC62_RS00430	37624..38046	-	423	WP_002450862.1	organic hydroperoxide resistance protein	-
FOC62_RS00435	38224..38940	+	717	WP_002450861.1	type I 3-dehydroquinate dehydratase	-
FOC62_RS00440	39018..39557	+	540	WP_002450860.1	nitroreductase	-
FOC62_RS00445	39666..39989	-	324	WP_002450859.1	thioredoxin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (88-134)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6991.71 Da
• Isoelectric Point: 10.1605

>T158516 WP_002450868.1 NZ_CP054017:c34965-34780 [Staphylococcus warneri]
MSLHFTILFWLSLIFIIAGAIILAIMLKTKKESKKESYLGFTIVFFIFGLAMLIYTLLFGL

Nucleotide

• Length: 186 bp

>T158516 NZ_CP069657:c2531055-2530879 [Escherichia coli O89m:H10]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9976.25 Da
• Isoelectric Point: 4.6285

>AT158516 WP_002450867.1 NZ_CP054017:c35242-34985 [Staphylococcus warneri]
MKRYILHAINIILTILLIIFNVIITYNTNLDETLWLVPGLIVCGLIMMISFTIAITIKDLLSEVLFFINIILTLYYIYPI
FYDFL

Nucleotide

• Length: 258 bp

>AT158516 NZ_CP069657:c2530833-2530417 [Escherichia coli O89m:H10]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA