Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/YoeB-RelB
Location 1930151..1930667 Replicon chromosome
Accession NZ_CP054015
Organism Streptococcus gallolyticus strain FDAARGOS_755

Toxin (Protein)


Gene name Txe Uniprot ID F5X0X3
Locus tag FOC63_RS09665 Protein ID WP_014620143.1
Coordinates 1930151..1930408 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID -
Locus tag FOC63_RS09670 Protein ID WP_013643111.1
Coordinates 1930401..1930667 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC63_RS09640 1925681..1926289 + 609 WP_009854174.1 TipC family immunity protein -
FOC63_RS09645 1926472..1927320 - 849 WP_012961961.1 MurR/RpiR family transcriptional regulator -
FOC63_RS09650 1927490..1928473 + 984 WP_009854176.1 Gfo/Idh/MocA family oxidoreductase -
FOC63_RS09655 1928478..1929002 + 525 WP_009854177.1 heme-binding protein -
FOC63_RS09660 1929023..1930081 + 1059 WP_009854178.1 Gfo/Idh/MocA family oxidoreductase -
FOC63_RS09665 1930151..1930408 - 258 WP_014620143.1 Txe/YoeB family addiction module toxin Toxin
FOC63_RS09670 1930401..1930667 - 267 WP_013643111.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC63_RS09675 1930831..1931163 + 333 WP_009854181.1 putative DNA-binding protein -
FOC63_RS09680 1931234..1932799 + 1566 WP_009854182.1 signal recognition particle protein -
FOC63_RS09685 1932865..1933881 - 1017 WP_009854183.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10277.64 Da        Isoelectric Point: 8.7825

>T158515 WP_014620143.1 NZ_CP054015:c1930408-1930151 [Streptococcus gallolyticus]
MIKAWSDDAWNDYMYWYNQGNKATIKKINRLIKEIDRTPFTGIGKPEPLKHDLSGKWSRRITDEHRLIYSVDETTIYFYS
CKDHY

Download         Length: 258 bp

>T158515 NZ_CP069657:2441003-2442325 [Escherichia coli O89m:H10]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10393.65 Da        Isoelectric Point: 4.6290

>AT158515 WP_013643111.1 NZ_CP054015:c1930667-1930401 [Streptococcus gallolyticus]
MEVVAYSNFRQNLKHYMKQVNDDAEPLIVTSKNIDDTVVVLSKRDYDSMQETFRIMSNNYLMNKIKRGDEQFKAANFQTH
ELLEVDDD

Download         Length: 267 bp

>AT158515 NZ_CP069657:2440737-2441003 [Escherichia coli O89m:H10]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S5WCL9

Antitoxin

Source ID Structure

References