Detailed information of TA system TA158514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1451447..1451933
• Replicon: chromosome
• Accession: NZ_CP054015
• Organism: Streptococcus gallolyticus strain FDAARGOS_755

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1S5WAV3
• Locus tag: FOC63_RS07465
• Protein ID: WP_009853752.1
• Coordinates: 1451664..1451933 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FOC63_RS07460
• Protein ID: WP_009853751.1
• Coordinates: 1451447..1451674 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC63_RS07415	1447150..1447587	+	438	WP_009853742.1	hypothetical protein	-
FOC63_RS07420	1447799..1447981	+	183	WP_009853743.1	hypothetical protein	-
FOC63_RS07425	1448078..1448656	+	579	WP_009853744.1	hypothetical protein	-
FOC63_RS07430	1448653..1448943	+	291	WP_009853745.1	hypothetical protein	-
FOC63_RS07435	1448895..1449296	+	402	WP_043878533.1	replication protein	-
FOC63_RS07440	1449292..1449651	+	360	WP_043878643.1	hypothetical protein	-
FOC63_RS07445	1449669..1450049	+	381	WP_009853748.1	hypothetical protein	-
FOC63_RS07450	1450196..1450396	+	201	WP_043878644.1	hypothetical protein	-
FOC63_RS07455	1450667..1451206	-	540	WP_009853750.1	hypothetical protein	-
FOC63_RS07460	1451447..1451674	+	228	WP_009853751.1	hypothetical protein	Antitoxin
FOC63_RS07465	1451664..1451933	+	270	WP_009853752.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC63_RS07470	1452313..1452879	-	567	WP_009853753.1	DUF3267 domain-containing protein	-
FOC63_RS07475	1453130..1453651	+	522	WP_009853754.1	transcription repressor NadR	-
FOC63_RS07480	1453848..1454402	+	555	WP_043878534.1	hypothetical protein	-
FOC63_RS07485	1454557..1456710	+	2154	WP_009853756.1	penicillin-binding protein PBP2B	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1443514..1452879	9365

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10554.64 Da
• Isoelectric Point: 10.4700

>T158514 WP_009853752.1 NZ_CP054015:1451664-1451933 [Streptococcus gallolyticus]
MTYRLVVSDKVKKQLKKMDKHVRLMLAKDMKKHLDGLENPRQIGKALIGQFKGLWRYRIGNYRVICDIMDDELVILAIEI
GHRKDIYKN

Nucleotide

• Length: 270 bp

>T158514 NZ_CP069657:2126908-2127011 [Escherichia coli O89m:H10]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8731.78 Da
• Isoelectric Point: 4.2925

>AT158514 WP_009853751.1 NZ_CP054015:1451447-1451674 [Streptococcus gallolyticus]
MSIVSLRLNEKEEELFRSYSIHTGKTLSELFKTALAEQIENQLDYETGIQALKEFKKNPVTHSIDDIIEEFENDL

Nucleotide

• Length: 228 bp

>AT158514 NZ_CP069657:c2127049-2126778 [Escherichia coli O89m:H10]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A1S5WAV3