Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/DinJ(antitoxin)
Location 173607..174213 Replicon chromosome
Accession NZ_CP054015
Organism Streptococcus gallolyticus strain FDAARGOS_755

Toxin (Protein)


Gene name parE Uniprot ID A0A1I7GRN0
Locus tag FOC63_RS00830 Protein ID WP_009854656.1
Coordinates 173607..173939 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1S5WDU6
Locus tag FOC63_RS00835 Protein ID WP_009854657.1
Coordinates 173929..174213 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC63_RS00805 169038..169646 - 609 WP_009854651.1 TVP38/TMEM64 family protein -
FOC63_RS00810 169894..170196 - 303 WP_009854652.1 PepSY domain-containing protein -
FOC63_RS00815 170439..171971 - 1533 WP_013643300.1 HAMP domain-containing histidine kinase -
FOC63_RS00820 171916..172608 - 693 WP_009854654.1 response regulator transcription factor -
FOC63_RS00825 172714..173592 - 879 WP_009854655.1 DUF3114 domain-containing protein -
FOC63_RS00830 173607..173939 - 333 WP_009854656.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FOC63_RS00835 173929..174213 - 285 WP_009854657.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FOC63_RS00840 174489..175007 + 519 WP_009854658.1 TetR/AcrR family transcriptional regulator -
FOC63_RS00845 175121..176890 + 1770 WP_009854659.1 oleate hydratase -
FOC63_RS00850 177020..177838 - 819 WP_009854660.1 class C sortase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(8-55)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 13018.00 Da        Isoelectric Point: 8.6852

>T158513 WP_009854656.1 NZ_CP054015:c173939-173607 [Streptococcus gallolyticus]
MDYKKYKLIYSQRVIDTLDDIYHYIANEIGSTINAKKKIASIRKDLQRLEFFPEGGFDADEKFGKCLDPKYKTRGLTLSK
DYIALYNILENEVRIAYLLPTRSDYMDLFR

Download         Length: 333 bp

>T158513 NZ_CP069657:1880473-1880727 [Escherichia coli O89m:H10]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11125.47 Da        Isoelectric Point: 4.7049

>AT158513 WP_009854657.1 NZ_CP054015:c174213-173929 [Streptococcus gallolyticus]
MALAYDKSYNLRTYQKIYNQAEKVFKENNLNTAQALNLFLKNVAETGQLNLKTEEELKREKLFKNLQAEIQQSYAEFDEG
KFYTDEDLVERYGL

Download         Length: 285 bp

>AT158513 NZ_CP069657:1880225-1880476 [Escherichia coli O89m:H10]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I7GRN0

Antitoxin

Source ID Structure
AlphaFold DB A0A1S5WDU6

References