Detailed information of TA system TA158512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 43227..43807
• Replicon: chromosome
• Accession: NZ_CP054015
• Organism: Streptococcus gallolyticus strain FDAARGOS_755

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: F5WVJ0
• Locus tag: FOC63_RS00215
• Protein ID: WP_009854536.1
• Coordinates: 43619..43807 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FOC63_RS00210
• Protein ID: WP_009854535.1
• Coordinates: 43227..43607 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC63_RS00200	38511..40346	-	1836	WP_003065532.1	translation elongation factor 4	-
FOC63_RS00205	40981..41397	-	417	WP_009854531.1	nucleoside-diphosphate kinase	-
FOC63_RS00210	43227..43607	-	381	WP_009854535.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FOC63_RS00215	43619..43807	-	189	WP_009854536.1	type II toxin-antitoxin system HicA family toxin	Toxin
FOC63_RS00220	43903..44568	-	666	WP_172855736.1	type II-A CRISPR-associated protein Csn2	-
FOC63_RS00225	44555..44899	-	345	WP_009854538.1	CRISPR-associated endonuclease Cas2	-
FOC63_RS00230	44896..45762	-	867	WP_009854539.1	type II CRISPR-associated endonuclease Cas1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6837.25 Da
• Isoelectric Point: 10.8207

>T158512 WP_009854536.1 NZ_CP054015:c43807-43619 [Streptococcus gallolyticus]
VPLTGRELAKLAVLKGWKEVRVKGSHHQFKKDGVPYILTIPIHGNKVLGVGLEKKILKDIGL

Nucleotide

• Length: 189 bp

>T158512 NZ_CP069657:1880225-1880476 [Escherichia coli O89m:H10]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14141.02 Da
• Isoelectric Point: 4.2393

>AT158512 WP_009854535.1 NZ_CP054015:c43607-43227 [Streptococcus gallolyticus]
MLKSYPAIFHKEDDGSFWVEFPGFGGGTEGDDVEEAMKNAREMLESSLAAYLDEGLELPKVVNMSELSVEDGFITLIQAD
PSPYLKSTKAIRKNVTVPEWLVRLADRENVNYSEVLTQALEKKLQL

Nucleotide

• Length: 381 bp

>AT158512 NZ_CP069657:1880473-1880727 [Escherichia coli O89m:H10]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A1S5WDX8