Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3940292..3940966 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag FOC64_RS18480 Protein ID WP_003417282.1
Coordinates 3940538..3940966 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag FOC64_RS18475 Protein ID WP_003417286.1
Coordinates 3940292..3940534 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS18450 3936828..3937892 + 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -
FOC64_RS18455 3937989..3938363 + 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
FOC64_RS18460 3938360..3938893 + 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
FOC64_RS18465 3938894..3939559 + 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
FOC64_RS18470 3939556..3940170 + 615 WP_003417288.1 class I SAM-dependent methyltransferase -
FOC64_RS18475 3940292..3940534 + 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
FOC64_RS18480 3940538..3940966 + 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS18485 3941045..3941836 - 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
FOC64_RS18490 3941836..3943608 - 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
FOC64_RS18495 3943737..3944171 - 435 WP_003902441.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
FOC64_RS18500 3944168..3944602 - 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
FOC64_RS18505 3944743..3945144 + 402 WP_003417264.1 cytidine deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T158510 WP_003417282.1 NZ_CP054014:3940538-3940966 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T158510 NZ_CP069657:1046804-1047139 [Escherichia coli O89m:H10]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT158510 WP_003417286.1 NZ_CP054014:3940292-3940534 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT158510 NZ_CP069657:1046556-1046804 [Escherichia coli O89m:H10]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References