Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3813566..3814272 Replicon chromosome
Accession NZ_CP054014
Organism Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag FOC64_RS18005 Protein ID WP_003417998.1
Coordinates 3813566..3813976 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5R1Z4U0
Locus tag FOC64_RS18010 Protein ID WP_003911013.1
Coordinates 3813973..3814272 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC64_RS17990 3809005..3810594 + 1590 WP_003901630.1 IMP dehydrogenase -
FOC64_RS17995 3810614..3811741 + 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
FOC64_RS18000 3811797..3813533 + 1737 WP_003418002.1 cholesterol oxidase -
FOC64_RS18005 3813566..3813976 - 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC64_RS18010 3813973..3814272 - 300 WP_003911013.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FOC64_RS18015 3814307..3815194 - 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
FOC64_RS18020 3815256..3815822 + 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
FOC64_RS18025 3815940..3816644 + 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
FOC64_RS18030 3816661..3818262 + 1602 WP_003417969.1 FAD/NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-65)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T158507 WP_003417998.1 NZ_CP054014:c3813976-3813566 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T158507 NZ_CP069657:719547-719843 [Escherichia coli O89m:H10]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10956.61 Da        Isoelectric Point: 9.2278

>AT158507 WP_003911013.1 NZ_CP054014:c3814272-3813973 [Mycobacterium tuberculosis]
MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEP
ARGCKRTLSDVLNEMRDEQ

Download         Length: 300 bp

>AT158507 NZ_CP069657:719845-720240 [Escherichia coli O89m:H10]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure
AlphaFold DB A0A5R1Z4U0

References