Detailed information of TA system TA158505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2899033..2899667
• Replicon: chromosome
• Accession: NZ_CP054014
• Organism: Mycobacterium tuberculosis strain FDAARGOS_756

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P9WF84
• Locus tag: FOC64_RS13850
• Protein ID: WP_003401406.1
• Coordinates: 2899239..2899667 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC64_RS13845
• Protein ID: WP_011961607.1
• Coordinates: 2899033..2899215 (+)
• Length: 61 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC64_RS13840	2896131..2898938	+	2808	WP_025202582.1	PE family protein	-
FOC64_RS13845	2899033..2899215	+	183	WP_011961607.1	hypothetical protein	Antitoxin
FOC64_RS13850	2899239..2899667	+	429	WP_003401406.1	type II toxin-antitoxin system VapC family toxin	Toxin
FOC64_RS13855	2899707..2900627	-	921	WP_003401404.1	DUF2236 domain-containing protein	-
FOC64_RS13860	2900717..2901442	+	726	WP_003899886.1	TetR/AcrR family transcriptional regulator	-
FOC64_RS13865	2901372..2901953	-	582	WP_003401399.1	VOC family protein	-
FOC64_RS13870	2902050..2902670	+	621	WP_003401397.1	TetR/AcrR family transcriptional regulator	-
FOC64_RS13875	2902667..2903800	+	1134	WP_003401394.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-133)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15887.27 Da
• Isoelectric Point: 7.2214

>T158505 WP_003401406.1 NZ_CP054014:2899239-2899667 [Mycobacterium tuberculosis]
MFLIDVNVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLTTNRRIFEIPSPRADAFAFVEAVNAQPHHL
PTSPGPRHLVLLRKLCDEADASGDLIPDAVLGAIAVEHHCAVVSLDRDFARFASVRHIRPPI

Nucleotide

• Length: 429 bp

>T158505 NZ_CP069657:c609631-609167 [Escherichia coli O89m:H10]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 61 a.a.
• Molecular weight: 6262.06 Da
• Isoelectric Point: 4.5878

>AT158505 WP_011961607.1 NZ_CP054014:2899033-2899215 [Mycobacterium tuberculosis]
MGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNTVLSEVLDEGLELNSRK

Nucleotide

• Length: 183 bp

>AT158505 NZ_CP069657:c609966-609631 [Escherichia coli O89m:H10]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A7U4BRM6